Comparison of the relative renal function evaluated by 99Tcm-DMSA and 99Tcm-DTPA imaging in children with acute urinary tract infection

中华核医学与分子影像杂志 Pub Date : 2019-12-25 DOI:10.3760/CMA.J.ISSN.2095-2848.2019.12.007

Xiaojia Pu, Wei Hu, Kejing Shao, Fei Wang

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Abstract

Objective To compare the relative renal function (RRF) evaluated by 99Tcm-dimercaptosuccinic acid (DMSA) and 99Tcm-diethylene triamine pentaacetic acid (DTPA) imaging in children with acute urinary tract infection (UTI). Methods A total of 69 children (29 males, 40 females, age: (45±38) months; duration of disease: <6 months) with acute UTI diagnosed clinically in Wuxi People′s Hospital from January 2017 to June 2019 were enrolled retrospectively. All children underwent 99Tcm-DMSA renal static imaging and 99Tcm-DTPA renal dynamic imaging, and the regions of interest (ROI) were drawn manually to calculate the RRF of the right and left kidneys. The consistency of RRF evaluated by the two imaging methods was analyzed by Bland-Altman analysis, the correlation was analyzed by Pearson correlation analysis, and the difference was compared by the independent-sample t test. Results The values of RRF measured with 99Tcm-DMSA and 99Tcm-DTPA were (52.27±14.53)% and (52.22±14.14)% for the left kidney (t=0.913, P>0.05), those for the right kidney were (47.73±14.53)% and (47.78±14.14)% (t=0.913, P>0.05), respectively. A significant positive correlation was found between the RRF measured with the two imaging methods both for left and right kidneys (r values: 0.959, 0.959; both P<0.01). Bland-Altman analysis showed that the average difference of RRF measured with the two imaging methods for left kidney was 0.1% and the 95% limits of agreement (LoA) was from -8.0% to 8.1%, those for right kidney were -0.1% and from -8.1% to 8.0%. Conclusions There is a good correlation between RRF measured with 99Tcm-DMSA renal static imaging and that measured with 99Tcm-DTPA renal dynamic imaging in children with acute UTI. Both imaging methods can be used to evaluate the RRF in children with acute UTI. Key words: Urinary tract infections; Infant; Child; Radionuclide imaging; Technetium Tc 99m dimercaptosuccinic acid; Technetium Tc 99m pentetate

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99Tcm-DMSA与99Tcm-DTPA对急性尿路感染患儿相对肾功能的评价

目的比较99tcm -二巯基琥珀酸(DMSA)与99tcm -二乙烯三胺五乙酸(DTPA)显像对急性尿路感染(UTI)患儿相对肾功能(RRF)的评价。方法患儿69例，男29例，女40例，年龄(45±38)个月;病程:0.05)，右肾组分别为(47.73±14.53)%、(47.78±14.14)% (t=0.913, P < 0.05)。两种影像学方法测得的左、右肾RRF呈显著正相关(r值分别为0.959、0.959;P < 0.01)。Bland-Altman分析显示，两种成像方法测得的左肾RRF平均差异为0.1%，95%一致限(LoA)为-8.0% ~ 8.1%，右肾RRF为-0.1%、-8.1% ~ 8.0%。结论急性UTI患儿99Tcm-DMSA肾脏静态显像与99Tcm-DTPA肾脏动态显像测量的RRF有较好的相关性。两种成像方法均可用于评估儿童急性尿路感染的RRF。关键词:尿路感染;婴儿;孩子;放射性核素成像;tc99m二巯基琥珀酸;锝Tc 99m穿透

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来源期刊

中华核医学与分子影像杂志核医学，分子影像

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发文量

5088

期刊介绍： Chinese Journal of Nuclear Medicine and Molecular Imaging (CJNMMI) was established in 1981, with the name of Chinese Journal of Nuclear Medicine, and renamed in 2012. As the specialized periodical in the domain of nuclear medicine in China, the aim of Chinese Journal of Nuclear Medicine and Molecular Imaging is to develop nuclear medicine sciences, push forward nuclear medicine education and basic construction, foster qualified personnel training and academic exchanges, and popularize related knowledge and raising public awareness. Topics of interest for Chinese Journal of Nuclear Medicine and Molecular Imaging include: -Research and commentary on nuclear medicine and molecular imaging with significant implications for disease diagnosis and treatment -Investigative studies of heart, brain imaging and tumor positioning -Perspectives and reviews on research topics that discuss the implications of findings from the basic science and clinical practice of nuclear medicine and molecular imaging - Nuclear medicine education and personnel training - Topics of interest for nuclear medicine and molecular imaging include subject coverage diseases such as cardiovascular diseases, cancer, Alzheimer’s disease, and Parkinson’s disease, and also radionuclide therapy, radiomics, molecular probes and related translational research.