Mitochondrial Dynamics and Its Involvement in Disease.

IF 28.4 1区医学 Q1 PATHOLOGY

Annual Review of Pathology-Mechanisms of Disease Pub Date : 2020-01-24 DOI:10.1146/annurev-pathmechdis-012419-032711

D. Chan

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引用次数: 520

Abstract

The dynamic properties of mitochondria-including their fusion, fission, and degradation-are critical for their optimal function in energy generation. The interplay of fusion and fission confers widespread benefits on mitochondria, including efficient transport, increased homogenization of the mitochondrial population, and efficient oxidative phosphorylation. These benefits arise through control of morphology, content exchange, equitable inheritance of mitochondria, maintenance of high-quality mitochondrial DNA, and segregation of damaged mitochondria for degradation. The key components of the machinery mediating mitochondrial fusion and fission belong to the dynamin family of GTPases that utilize GTP hydrolysis to drive mechanical work on biological membranes. Defects in this machinery cause a range of diseases that especially affect the nervous system. In addition, several common diseases, including neurodegenerative diseases and cancer, strongly affect mitochondrial dynamics. Expected final online publication date for the Annual Review of Pathology: Mechanisms of Disease, Volume 15 is January 24, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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线粒体动力学及其在疾病中的作用。

线粒体的动力学特性，包括它们的融合、裂变和降解，对于它们在能量产生中的最佳功能至关重要。融合和裂变的相互作用为线粒体带来了广泛的好处，包括有效的运输、线粒体群体的同质化增加和有效的氧化磷酸化。这些益处通过控制形态、内容交换、线粒体的公平遗传、维持高质量的线粒体DNA以及分离受损线粒体进行降解而产生。介导线粒体融合和分裂的机制的关键成分属于GTP酶的动力蛋白家族，该家族利用GTP水解来驱动生物膜上的机械工作。这种机器的缺陷会导致一系列疾病，尤其是影响神经系统。此外，包括神经退行性疾病和癌症在内的几种常见疾病强烈影响线粒体动力学。《病理学年度评论：疾病机制》第15卷预计最终在线出版日期为2020年1月24日。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual Review of Pathology-Mechanisms of Disease 医学-病理学

CiteScore

62.60

自引率

0.00%

发文量

期刊介绍： The Annual Review of Pathology: Mechanisms of Disease is a scholarly journal that has been published since 2006. Its primary focus is to provide a comprehensive overview of recent advancements in our knowledge of the causes and development of significant human diseases. The journal places particular emphasis on exploring the current and evolving concepts of disease pathogenesis, as well as the molecular genetic and morphological changes associated with various diseases. Additionally, the journal addresses the clinical significance of these findings. In order to increase accessibility and promote the broad dissemination of research, the current volume of the journal has transitioned from a gated subscription model to an open access format. This change has been made possible through the Annual Reviews' Subscribe to Open program, which allows all articles published in this volume to be freely accessible to readers. As part of this transition, all articles in the journal are published under a Creative Commons Attribution (CC BY) license, which encourages open sharing and use of the research.