{"title":"SARS-CoV-2 RT-PCR positivity rate and predictor factors for RT-PCR results in COVID-19 disease","authors":"Melike Badoglu, S. Gulgosteren, Ş. Atikcan","doi":"10.4103/jacp.jacp_36_21","DOIUrl":null,"url":null,"abstract":"Background/Aim: In December 2019, a novel coronavirus was identified and caused the SARS-CoV-2 (COVID-19) pandemic. The gold standard diagnostic method is the detection of nucleic acid in respiratory tract samples by real-time polymerase chain reaction (RT-PCR). But there might be false-negative results. The aim of this retrospective study was to find the SARS-CoV-2 RT-PCR positivity rate in patients hospitalized due to viral pneumonia consistent with COVID-19 disease and to find predictor factors for RT-PCR results. Materials and methods: Adult (≥18 years of age) patients hospitalized due to viral pneumonia consistent with COVID-19 were enrolled. Results: One hundred ninety-one patients were enrolled in the study. Sixty six (34.6%) were female, and 125 (65.4%) were male. The mean age was 59.7. The RT-PCR positivity rate was 11.5%. Smoking status, confirmed fever, bronchial changes, left lower lobe involvement, and ≥3 affected lobes in CT, leukopenia, high PCT level, and <3 RT-PCR examinations per patient were found to be independent factors for the PCR result (P < 0.05). Conclusion: We found independent predictors for SARS-CoV-2 RT-PCR positivity and negativity in viral pneumonia consistent with COVID-19. Despite false negative results, COVID-19 patients could be diagnosed with the help of clinical, laboratory, and radiological findings.","PeriodicalId":30411,"journal":{"name":"The Journal of Association of Chest Physicians","volume":"11 1","pages":"81 - 84"},"PeriodicalIF":0.0000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Association of Chest Physicians","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/jacp.jacp_36_21","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background/Aim: In December 2019, a novel coronavirus was identified and caused the SARS-CoV-2 (COVID-19) pandemic. The gold standard diagnostic method is the detection of nucleic acid in respiratory tract samples by real-time polymerase chain reaction (RT-PCR). But there might be false-negative results. The aim of this retrospective study was to find the SARS-CoV-2 RT-PCR positivity rate in patients hospitalized due to viral pneumonia consistent with COVID-19 disease and to find predictor factors for RT-PCR results. Materials and methods: Adult (≥18 years of age) patients hospitalized due to viral pneumonia consistent with COVID-19 were enrolled. Results: One hundred ninety-one patients were enrolled in the study. Sixty six (34.6%) were female, and 125 (65.4%) were male. The mean age was 59.7. The RT-PCR positivity rate was 11.5%. Smoking status, confirmed fever, bronchial changes, left lower lobe involvement, and ≥3 affected lobes in CT, leukopenia, high PCT level, and <3 RT-PCR examinations per patient were found to be independent factors for the PCR result (P < 0.05). Conclusion: We found independent predictors for SARS-CoV-2 RT-PCR positivity and negativity in viral pneumonia consistent with COVID-19. Despite false negative results, COVID-19 patients could be diagnosed with the help of clinical, laboratory, and radiological findings.