An Evaluation of Effects of Black Grape and Ginger Extracts on Hematological Alteration and Lipid Peroxidation of Hepatocyte in Irradiated Albino Mice

Abstract

Introduction: Exposure to ionizing radiation can trigger adverse biological effects on healthy tissues, such as causing hematological toxicity and potential injury to different organs. Ionizing radiation has sufficient energy to liberate electrons from atoms leaving them with unpaired electrons; hence ionizing them and producing free radicals. In the current study, the risk of exposing to 6 Gy x-irradiation on alteration of some hematological parameters and liver tissue lipid peroxidation activity in albino mice in the presence and absence of black grape and ginger extracts as antioxidants have been investigated. Material and Methods: Albino mice were exposed to 6 Gy wholebody xirradiation in the absence and presence of black grape and ginger extracts (10mL/Kg). Results: The results of the present study showed a significant decrease in mice red blood cell count, hemoglobin, hematocrit, mean corpuscular volume, and mean corpuscular hemoglobin, following the exposure to 6 Gy x-irradiation (P≤0.05), while all the mentioned parameters were relatively shifted toward the normal values in the mice that received black grape and ginger extracts as a treatment prior to the radiation. Accordingly, our results demonstrated a noticeable increase in the malondialdehyde analysis (MDA) level in the 6 Gy group, while a slight depletion in the MDA level was observed in the group of mice that received black grape and ginger extracts, compared to that of the control group.  Conclusion: the administration of black grape and ginger extracts prior to irradiation may protect the mice from excess hepatocyte lipid peroxidation and alteration of hematological parameters.