Adaptive Mechanisms of a Mouse Locomotor Muscles "M. Soleus" and "M. Edl" the Conditions of the Allergic Modification of the Organism

Abstract

The relevance of the problem discussed in the article is connected to the fact that mandatory athletes’ vaccination before competitions leads to the change in the function of the muscular system, the mechanisms of which have not yet been fully clarified. The purpose of the article is to determine the mechanism of a mouse skeletal muscles adaptation (SM) ("fast" (in case of m.edl) and "slow" (in case of m.soleus) in case of allergic alteration. The following research methods were used in the presented work: registration of the constrictive function of the abovementioned muscles in vitro to the humoral constriction initiators (carbacholinum and KCI) and determination of malonyldialdehyde (MDA) level in them, just as the indicators of the oxidant and antioxidant equilibrium. It has been demonstrated that the change in the “slow” muscle strength correlates with the MDA level dynamics, evidently, reflects the adaptation processes during the allergic modification. "Fast" muscles turn out to be more sustainable to oxidative stress which is most probably achieved by the work of compensatory mechanisms and is expressed in quite minor changes in the MDA dynamics. The article can be used in the search of the new possibilities for the correction of the locomotor muscles function in the conditions of the allergy, аnd also while the therapeutic impact strategy is determined, taking into account their fiber composition.