Effect of vitamin D supplementation on serum lipid profiles in children and adolescence: A meta-analysis

IF 0.3 Q4 PEDIATRICS
B. Amiri, K. Namakin, M. Soltani, Sameep S. Shetty, S. Riahi
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引用次数: 1

Abstract

Background: Vitamin D deficiency is an important risk factor for some chronic disease. Some reports suggested that there is an interrelationship between lipids and cholecalciferol. Objectives: This meta-analysis was conducted to summarize the existing evidence of randomized controlled trial (RCTs) to evaluate the effect of vitamin D supplementation on lipid profiles in children and adolescents. Methods: In this systematic review and meta-analysis data base such as Web of Science, PubMed, Scopus, Google Scholar, EMBASE, Science Direct, Magiran, SID were searched for studies prior up to December 21st, 2019. This study was conducted according to PRISMA guidelines. I-square was used to measure the existing heterogeneity through included articles. Considering heterogeneity among articles, random-effect models were applied to pool standardized mean differences (SMD) as overall effect size. P-value <0.05 was considered statistically significant. The analyses were conducted by STATA v 14.0. Study eligibility criteria included Children and adolescents (<18 years) and evaluated the association between vitamin D and lipid profile. Results: A total of 13 trials (number of participant=173) were included in the current meta-analysis. The SMD is 0.23, the vitamin D supplementation is associated with significant slight increase in high-density lipoproteins (HDL) levels in children and adolescent (SMD 0.23; 95% CI, 0.02, 0.45, P= 0.036; I2= 57.7%, Egger’s P=0.554). We found no significant association between vitamin D supplementation and LDL-cholesterol levels (SMD -0.10; 95% CI, − 0.29, 0.09, P = 0.310 ; I2 = 0.0%, Egger’s P=0.689), Total cholesterol  levels (SMD –0.01; 95% CI, − 0.20, 0.18, P = 0.926 ; I2 = 0.0%, Egger’s P=0.005) and triglycerides levels (SMD -0.10; 95% CI, − 0.22, 0.02, P = 0.093 ; I2 = 0.0%, Egger’s P=0.160). Conclusions and implications: vitamin D could marginally increase HDL level, without any significant effect on LDL-C, TG, and TC levels.
补充维生素D对儿童和青少年血脂水平的影响:一项荟萃分析
背景:维生素D缺乏是某些慢性病的重要危险因素。一些报道表明,脂质和胆钙化醇之间存在相互关系。目的:本荟萃分析旨在总结随机对照试验(RCTs)的现有证据,以评估补充维生素D对儿童和青少年脂质状况的影响。方法:在本系统综述和荟萃分析数据库中,检索截至2019年12月21日的研究,如Web of Science、PubMed、Scopus、Google Scholar、EMBASE、Science Direct、Magiran、SID。本研究根据PRISMA指南进行。I-square用于通过纳入的文章来衡量现有的异质性。考虑到文章之间的异质性,应用随机效应模型将标准化平均差(SMD)作为总体效应大小。P值<0.05被认为具有统计学意义。这些分析是通过STATA v 14.0进行的。研究合格标准包括儿童和青少年(<18岁),并评估维生素D与脂质状况之间的关系。结果:共有13项试验(参与者人数=173)被纳入当前的荟萃分析。SMD为0.23,补充维生素D与儿童和青少年高密度脂蛋白(HDL)水平的显著轻微增加有关(SMD 0.23;95%CI,0.020.45,P=0.036;I2=57.7%,Egger’s P=0.554)。我们发现补充维生素D和LDL胆固醇水平之间没有显著关联(SMD-0.10;95%CI−0.29,0.09,P=0.310;I2=0.0%,Egger's P=0.689),总胆固醇水平(SMD–0.01;95%置信区间,−0.20,0.18,P=0.926;I2=0.0%,Egger’s P=0.005)和甘油三酯水平(SMD-0.10;95%可信区间,−0.22,0.02,P=0.093;I2=0.00%,Egger‘s P=0.160)。结论和意义:维生素D可以略微增加HDL水平,对LDL-C、TG和TC水平没有任何显著影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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