{"title":"A biosensor based on a modified S-taper fiber for target protein detection","authors":"Xiaoqi Liu, Yange Liu, Zhi Wang","doi":"10.1016/j.npe.2020.08.002","DOIUrl":null,"url":null,"abstract":"<div><p>A biosensor based on a modified S-taper fiber was proposed and experimentally demonstrated for antigen detection. Antibody was immobilized over the activated S-taper waist, where the fiber detected the interaction between the antibody and target antigen. Compared with a unmodified S-taper fiber structure, the silanized fiber had a detection limit of approximately 8.33 × 10<sup>−5</sup> RIU when the concentration of antigen solution was changed 1%. The antibody and antigen binding processing was monitored in real time by analyzing and investigating the transmission spectral characteristics of the modified S-taper fiber. The cost-effectiveness, real-time detection, and high integration properties of the fiber enable its use in a modal interferometer for biosensing applications including disease diagnosis and biological specificity recognition.</p></div>","PeriodicalId":87330,"journal":{"name":"Nanotechnology and Precision Engineering","volume":"3 3","pages":"Pages 162-166"},"PeriodicalIF":2.7000,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.npe.2020.08.002","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanotechnology and Precision Engineering","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2589554020300258","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
A biosensor based on a modified S-taper fiber was proposed and experimentally demonstrated for antigen detection. Antibody was immobilized over the activated S-taper waist, where the fiber detected the interaction between the antibody and target antigen. Compared with a unmodified S-taper fiber structure, the silanized fiber had a detection limit of approximately 8.33 × 10−5 RIU when the concentration of antigen solution was changed 1%. The antibody and antigen binding processing was monitored in real time by analyzing and investigating the transmission spectral characteristics of the modified S-taper fiber. The cost-effectiveness, real-time detection, and high integration properties of the fiber enable its use in a modal interferometer for biosensing applications including disease diagnosis and biological specificity recognition.
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