The Effect of N-butyl-2-Cyanoacrylate on Wound Healing in Head Neck Region

Abstract

OBJECTIVE To compare the histological regeneration characteristics of open wound on head neck by a topical antiseptic solution (Batticon ® solution 5%; Adeka, Samsun, Turkey ) or a tissue adhesive (N-butyl-2-cyanoacrylate, Glubran 2, GEM Company, Italy) in experimentally created rabbit auricular open wound. MATERIAL AND METHOD Twenty-eight female rabbits (New Zealand genus), weighing 3 to 4 kg, were handled daily for 2 weeks prior to surgical manipulation to condition them to behavior testing. The control group consisted of seven rabbits. The 21 rabbits were randomly divided into three groups based on the harvesting day. In control group a segment of ear auricula was resected and sent to histological examination for comparison with the study group findings. In the study group both auricular skin of each animal was exposed and 1x1 cm epidermal resection area was created open wound in rabbit ears that is to be a model for open tissue injury and applied as a topical antiseptic solution (Batticon ® solution 5%; Adeka, Samsun, Turkey) on one side and by application of tissue adhesive (Glubran 2, GEM Company, Italy) on the other side. Following this application at 2 nd , 4 th and 6th days the animals were harvested and histological regeneration characteristics of open wound examined by electron microscopy and compared to the control group’s histological findings. RESULTS Electron microscopic examination of open wound at consecutive 2 nd , 4 th and 6 th days revealed increased regeneration findings in tissue adhesive group when compared to a antiseptic solution group. CONCLUSION Based on the findings of this animal study we conclude that N-butyl-2-cyanoacrylate is an appropriate material for open wound on head and neck region.