Trends in TC/HDL and LDL/HDL Ratios across the Age Span: Data from the 2007-2018 National Health and Nutrition Examination Survey (NHANES)

Inga Wang, Jay Kapellush, Stephen Hou, M. Rahman, Xiaoyan Li, David Ritchie
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Abstract

Background. Cholesterol levels in total cholesterol (TC), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), and triglyceride (TG) contribute to atherosclerosis and its clinical consequences. Objectives. This study aimed to examine the trends in serum TC/HDL and LDL/HDL ratio across the age span. Methods. This is an observational study. Blood lipid measurements, taken from 85,646 noninstitutionalized participants, aged 6 to 80, were obtained from the National Health and Nutrition Examination Survey (NHANES) study. We compared the TC/HDL and LDL/HDL ratio trends in three distinct cross-sectional surveys during 2007-2010, 2011-2014, and 2015- 2018. Results. Cholesterol ratios changed by age and differed by sex. Mean TC/HDL ratios declined from 4.03 (95% CI, 4.01-4.05) in 2007-2010, to 3.84 (95% CI, 3.81-3.87) in 2015-2018 (p<.05 for linear trend) in male; mean TC/HDL ratios declined from 3.69 (95% CI, 3.67-3.70) in 2007- 2010, to 3.45 (95% CI, 3.42-3.47) in 2015-2018 (p<.05 for linear trend) in female. Mean LDL/HDL ratios declined from 2.30 (95% CI, 2.28-2.32) in 2007-2010, to 2.18 (95% CI, 2.15- 2.20) in 2015-2018 (p<.05 for linear trend) in male; mean LDL/HDL ratios declined from 2.04 (95% CI, 2.02-2.06) in 2007-2010, to 1.96 (95% CI, 1.94-1.98) in 2015-2018 (p<.001 for linear trend) in female. Conclusions. Between 2007 and 2018, favorable trends in lipid ratio levels were observed among noninstitutionalized residents in the US.
TC/HDL和LDL/HDL比值在整个年龄段的趋势:来自2007-2018年全国健康和营养检查调查(NHANES)的数据
背景。总胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)和甘油三酯(TG)中的胆固醇水平与动脉粥样硬化及其临床后果有关。目标。本研究旨在探讨血清TC/HDL和LDL/HDL比值在不同年龄段的变化趋势。方法。这是一项观察性研究。从国家健康与营养检查调查(NHANES)研究中获得了85,646名年龄在6至80岁之间的非机构参与者的血脂测量数据。我们比较了2007-2010年、2011-2014年和2015- 2018年三个不同的横断面调查中TC/HDL和LDL/HDL比率的趋势。结果。胆固醇比率随年龄和性别而变化。平均TC/HDL比值从2007-2010年的4.03 (95% CI, 4.01-4.05)下降到2015-2018年的3.84 (95% CI, 3.81-3.87) (p< 0.05)。男性为线性趋势0.05);平均TC/HDL比值从2007- 2010年的3.69 (95% CI, 3.67-3.70)下降到2015-2018年的3.45 (95% CI, 3.42-3.47) (p< 0.05)。05为线性趋势)。平均LDL/HDL比值从2007-2010年的2.30 (95% CI, 2.28-2.32)下降到2015-2018年的2.18 (95% CI, 2.15- 2.20) (p< 0.05)。男性为线性趋势0.05);平均LDL/HDL比值从2007-2010年的2.04 (95% CI, 2.02-2.06)下降到2015-2018年的1.96 (95% CI, 1.94-1.98) (p< 0.05)。001表示线性趋势)。结论。在2007年至2018年期间,在美国非机构居民中观察到脂质比率水平的有利趋势。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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