Incidence and risk factors of peripartum mood disorder: a prospective cohort study

Q4 Medicine

中华围产医学杂志 Pub Date : 2019-12-16 DOI:10.3760/CMA.J.ISSN.1007-9408.2019.12.005

Hanxiao Zuo, Xiaohong Xu, C. Ren, Ming-Feng Cui, Dongming Huang, Rong Mi, Li Li, Q. Xiu, Y. Lyu

{"title":"Incidence and risk factors of peripartum mood disorder: a prospective cohort study","authors":"Hanxiao Zuo, Xiaohong Xu, C. Ren, Ming-Feng Cui, Dongming Huang, Rong Mi, Li Li, Q. Xiu, Y. Lyu","doi":"10.3760/CMA.J.ISSN.1007-9408.2019.12.005","DOIUrl":null,"url":null,"abstract":"Objective \nTo investigate the incidence and risk factors of peripartum mood disorder (PPMD) in order to improve clinical prevention and intervention of this condition. \n \n \nMethods \nThis was a prospective cohort study recruiting first-trimester pregnant women (<13 gestational weeks) from Beijing Daxing Maternal and Child Care Hospital from October 1, 2016 to December 31, 2017. Zung Self-rating Anxiety Scale (SAS) and Zung Self-rating Depression Scale (SDS) were used to evaluate the anxiety and depression status in the second and third trimesters, respectively. Their life styles, social and environmental factors exposure during pregnancy were also collected. Statistical analysis was conducted using Chi-square test, student's t test, Mann-Whitney U test and multivariate logistic regression. \n \n \nResults \n(1) A total of 478 subjects were enrolled in early pregnancy and 460 (96.2%) and 431 (90.2%) of them completed SAS and SDS assessment in the second and third trimesters, respectively, and 413 (86.4%) of the subjects finished both assessments on two occasions. (2) The prevalence of anxiety and depression was 7.1% (30/425) and 13.9% (59/425) in the second trimester, and 11.2% (44/392) and 21.5% (84/390) in the third. The incidence of anxiety and depression in the third trimester was 7.7% (26/336) and 9.6% (30/313). (3) Cross-sectional data analysis showed that prolonged television watching was a risk factor of anxiety in the second (OR=1.216, 95%CI: 1.055-1.402) and third (OR=1.166, 95%CI: 1.044-1.303) trimester, while exercise was a protect factor (OR=0.238, 95%CI: 0.105-0.541; OR=0.432, 95%CI: 0.212-0.879). Pregnant women with longer sleeping time had lower risks of depression in the second trimester (OR=0.725, 95%CI: 0.554-0.950); those who did exercise had lower risks of depression in the third trimester (OR=0.450, 95%CI: 0.252-0.803). (4) Longitudinal-data analysis revealed that longer television watching time in the second trimester was a risk factor for anxiety (OR=1.264, 95%CI: 1.117-1.432) and depression (OR=1.119, 95%CI: 1.005-1.246) in the third trimester. \n \n \nConclusions \nThe prevalence of anxiety and depression in the third trimester is higher than that in the second trimester. The incidence of depression is higher than that of anxiety in the third trimester. Prolonged television viewing time in the second trimester is a risk factor for both anxiety and depression in the third trimester. \n \n \nKey words: \nMood disorders; Peripartum period; Incidence; Risk factors; Cohort studies","PeriodicalId":52320,"journal":{"name":"中华围产医学杂志","volume":"22 1","pages":"859-866"},"PeriodicalIF":0.0000,"publicationDate":"2019-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华围产医学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1007-9408.2019.12.005","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Objective To investigate the incidence and risk factors of peripartum mood disorder (PPMD) in order to improve clinical prevention and intervention of this condition. Methods This was a prospective cohort study recruiting first-trimester pregnant women (<13 gestational weeks) from Beijing Daxing Maternal and Child Care Hospital from October 1, 2016 to December 31, 2017. Zung Self-rating Anxiety Scale (SAS) and Zung Self-rating Depression Scale (SDS) were used to evaluate the anxiety and depression status in the second and third trimesters, respectively. Their life styles, social and environmental factors exposure during pregnancy were also collected. Statistical analysis was conducted using Chi-square test, student's t test, Mann-Whitney U test and multivariate logistic regression. Results (1) A total of 478 subjects were enrolled in early pregnancy and 460 (96.2%) and 431 (90.2%) of them completed SAS and SDS assessment in the second and third trimesters, respectively, and 413 (86.4%) of the subjects finished both assessments on two occasions. (2) The prevalence of anxiety and depression was 7.1% (30/425) and 13.9% (59/425) in the second trimester, and 11.2% (44/392) and 21.5% (84/390) in the third. The incidence of anxiety and depression in the third trimester was 7.7% (26/336) and 9.6% (30/313). (3) Cross-sectional data analysis showed that prolonged television watching was a risk factor of anxiety in the second (OR=1.216, 95%CI: 1.055-1.402) and third (OR=1.166, 95%CI: 1.044-1.303) trimester, while exercise was a protect factor (OR=0.238, 95%CI: 0.105-0.541; OR=0.432, 95%CI: 0.212-0.879). Pregnant women with longer sleeping time had lower risks of depression in the second trimester (OR=0.725, 95%CI: 0.554-0.950); those who did exercise had lower risks of depression in the third trimester (OR=0.450, 95%CI: 0.252-0.803). (4) Longitudinal-data analysis revealed that longer television watching time in the second trimester was a risk factor for anxiety (OR=1.264, 95%CI: 1.117-1.432) and depression (OR=1.119, 95%CI: 1.005-1.246) in the third trimester. Conclusions The prevalence of anxiety and depression in the third trimester is higher than that in the second trimester. The incidence of depression is higher than that of anxiety in the third trimester. Prolonged television viewing time in the second trimester is a risk factor for both anxiety and depression in the third trimester. Key words: Mood disorders; Peripartum period; Incidence; Risk factors; Cohort studies

查看原文本刊更多论文

围产期情绪障碍的发生率及危险因素:一项前瞻性队列研究

目的探讨围生期情绪障碍(PPMD)的发生率及危险因素，以提高围生期情绪障碍的临床预防和干预水平。方法采用前瞻性队列研究，招募2016年10月1日至2017年12月31日在北京大兴妇幼保健院就诊的早期妊娠(<13孕周)孕妇。采用Zung焦虑自评量表(SAS)和Zung抑郁自评量表(SDS)分别评价妊娠中期和晚期的焦虑和抑郁状况。同时收集她们的生活方式、孕期社会环境因素暴露情况。统计学分析采用卡方检验、学生t检验、Mann-Whitney U检验和多元logistic回归。结果(1)共纳入478例早孕受试者，其中460例(96.2%)和431例(90.2%)分别在妊娠中期和晚期完成了SAS和SDS评估，其中413例(86.4%)两次同时完成了SAS和SDS评估。(2)妊娠中期焦虑和抑郁患病率分别为7.1%(30/425)和13.9%(59/425)，妊娠晚期焦虑和抑郁患病率分别为11.2%(44/392)和21.5%(84/390)。妊娠晚期焦虑和抑郁发生率分别为7.7%(26/336)和9.6%(30/313)。(3)横断面数据分析显示，长时间看电视是妊娠中期(OR=1.216, 95%CI: 1.055 ~ 1.402)和妊娠晚期(OR=1.166, 95%CI: 1.044 ~ 1.303)焦虑的危险因素，而运动是妊娠中期焦虑的保护因素(OR=0.238, 95%CI: 0.105 ~ 0.541);Or =0.432, 95%ci: 0.212-0.879)。妊娠中期睡眠时间较长的孕妇患抑郁症的风险较低(OR=0.725, 95%CI: 0.554 ~ 0.950);锻炼的孕妇在妊娠晚期患抑郁症的风险较低(OR=0.450, 95%CI: 0.252-0.803)。(4)纵向数据分析显示，妊娠中期较长的电视观看时间是妊娠晚期焦虑(OR=1.264, 95%CI: 1.117 ~ 1.432)和抑郁(OR=1.119, 95%CI: 1.005 ~ 1.246)的危险因素。结论妊娠晚期焦虑和抑郁的发生率高于妊娠中期。妊娠晚期抑郁的发生率高于焦虑。妊娠中期看电视时间过长是妊娠晚期焦虑和抑郁的危险因素。关键词:情绪障碍;Peripartum时期;发病率;风险因素;队列研究

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

中华围产医学杂志 Medicine-Obstetrics and Gynecology

CiteScore

0.70

自引率

0.00%

发文量

4446

期刊介绍： Chinese Journal of Perinatal Medicine was founded in May 1998. It is one of the journals of the Chinese Medical Association, which is supervised by the China Association for Science and Technology, sponsored by the Chinese Medical Association, and hosted by Peking University First Hospital. Perinatal medicine is a new discipline jointly studied by obstetrics and neonatology. The purpose of this journal is to "prenatal and postnatal care, improve the quality of the newborn population, and ensure the safety and health of mothers and infants". It reflects the new theories, new technologies, and new progress in perinatal medicine in related disciplines such as basic, clinical and preventive medicine, genetics, and sociology. It aims to provide a window and platform for academic exchanges, information transmission, and understanding of the development trends of domestic and foreign perinatal medicine for the majority of perinatal medicine workers in my country.