In vivo and in vitro anti-schistosomiasis effect of garlic (Allium sativum): a systematic review.

Q3 Pharmacology, Toxicology and Pharmaceutics

Current drug discovery technologies Pub Date : 2022-02-28 DOI:10.2174/1570163819666220228154752

P. Shakib, H. Kalani, Ali Safar Maken Ali, Mustafa Zebardastpour, K. Moradpour, J. Ho, Vahideh Heydari Nazarabad, Kourosh Cheraghipour

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引用次数: 0

Abstract

BACKGROUND Garlic (Allium sativum) is currently used as a natural supplement for the treatment of various diseases and disorders, because it has antibacterial, antiviral, antifungal, antiparasitic, antioxidant, and anti-inflammatory properties. This systematic review aimed to summarize the in vitro and in vivo effects of garlic against Schistosoma spp. METHOD The current study was carried out according to the PRISMA guideline and registered in the CAMARADES-NC3Rs Preclinical Systematic Review and Meta-analysis Facility (SyRF) database. Literature search was conducted using five databases; namely Scopus, PubMed, Web of Science, EMBASE, and Google Scholar from January 2008 to January 2021. The search was restricted to articles published in English language. The search was performed using appropriate syntax and specific tags for each database. RESULTS Of 2,600 studies, 10 met the eligibility criteria for review. All studies used Schistosoma mansoni and garlic. Ten studies (90%) were performed in vivo and one study in vitro. The results of studies showed that garlic can remove the parasite through a direct effect on the parasite itself, such as changes in the parasite's coat or destruction of its spines, or indirectly by strengthening the immune response against the parasite. CONCLUSION Effective anti-schistosomal responses of garlic in studies show that the active compounds of garlic can be used as a complement with chemical drugs or as an alternative for them, and this is needed to optimize the consumption of these active compounds for medicinal uses.

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大蒜体内外抗血吸虫病作用的系统综述。

大蒜(Allium sativum)目前被用作治疗各种疾病和失调的天然补充剂，因为它具有抗菌、抗病毒、抗真菌、抗寄生虫、抗氧化和抗炎的特性。方法本研究按照PRISMA指南进行，并在CAMARADES-NC3Rs临床前系统评价和荟萃分析设施(SyRF)数据库中注册。文献检索使用5个数据库;即Scopus, PubMed, Web of Science, EMBASE和谷歌Scholar，从2008年1月到2021年1月。搜索仅限于用英语发表的文章。使用适当的语法和针对每个数据库的特定标记执行搜索。结果在2600项研究中，有10项符合审查的资格标准。所有的研究都使用了曼氏血吸虫和大蒜。10项研究(90%)在体内进行，1项研究在体外进行。研究结果表明，大蒜可以通过对寄生虫本身的直接作用(如改变寄生虫的外壳或破坏其刺)或通过加强对寄生虫的免疫反应来间接去除寄生虫。结论大蒜的抗血吸虫活性研究表明，大蒜活性成分可作为化学药物的补充或替代药物，需要对其药用活性成分的用量进行优化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current drug discovery technologies Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

3.70

自引率

0.00%

发文量

期刊介绍： Due to the plethora of new approaches being used in modern drug discovery by the pharmaceutical industry, Current Drug Discovery Technologies has been established to provide comprehensive overviews of all the major modern techniques and technologies used in drug design and discovery. The journal is the forum for publishing both original research papers and reviews describing novel approaches and cutting edge technologies used in all stages of drug discovery. The journal addresses the multidimensional challenges of drug discovery science including integration issues of the drug discovery process.