Hepatitis C virus genotype analysis in patients with chronic hepatitis in North Eastern Bulgaria.

IF 2.4
Journal of Drug Assessment Pub Date : 2019-08-08 eCollection Date: 2019-01-01 DOI:10.1080/21556660.2019.1654484
Zarina Brady, Zhivka Stoykova
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引用次数: 0

Abstract

Background: The main objective of this study was to analyse the spread of hepatitis C virus (HCV) genotype in patients with chronic liver disease; commenting on the molecular characterization of HCV and gender and age in Varna, Bulgaria. Across Europe and the world, HCV is a significant economic concern and public health crisis. Defined by genotype variations, HCV is the leading cause of chronic liver disease, liver related morbidity, and mortality worldwide. Active examination for asymptomatic patients is essential, initiating early treatment aimed at the specific HCV genotype, effective outcomes, and reducing transmission and mortality in Bulgaria. Methods and materials: Nucleic acid extraction and amplification were performed with commercially available test kits on 115 patients blood samples collected from March 2018 to October 2018. Male (n = 58) (50.43%, 95% CI = 41.29%-59.57%) and female (n = 57) (49.57%, 95% CI = 41.29%-59.57%) samples were equally distributed (mean age = 51.4 years; SD = ±16.5 years; range = 17-87 years old). Results: Genotype 1b predominated (73%, 95% CI = 64.89%-81.11%), followed by high prevalence of 1a (13.9%, 95% CI = 7.58%-20.22%) and 3 genotypes (11.3%, 95% CI = 5.51%-17.09%). Genotypes 2 and 4 were equally the least prevalent (0.9%, 95% CI = -0.83%-2.63%). In genotype 1b, 60.7% were women and 39.3% were men; in genotype 1a, 25% were women and 75% were men; and in genotype 3, only 7.7% were women and 92.3% were men. Males were most prevalent in genotypes 1a (75%) and 3 (92.3%), while women were most prevalent in genotype 1b (60.7%). Conclusions: HCV genotype lb is the predominant variant within the epidemiological pattern of HCV genotypes in patients with chronic liver diseases in North Eastern Bulgaria.

保加利亚东北部慢性肝炎患者丙型肝炎病毒基因型分析
摘要背景:本研究的主要目的是分析丙型肝炎病毒(HCV)基因型在慢性肝病患者中的传播;对保加利亚瓦尔纳丙型肝炎病毒的分子特征以及性别和年龄进行评论。在整个欧洲和世界范围内,丙型肝炎病毒是一个重大的经济问题和公共卫生危机。根据基因型变异的定义,HCV是全球慢性肝病、肝脏相关发病率和死亡率的主要原因。在保加利亚,对无症状患者进行积极检查至关重要,可以针对特定的HCV基因型进行早期治疗,取得有效的结果,并降低传播和死亡率。方法和材料:使用市售检测试剂盒对2018年3月至2018年10月采集的115名患者血样进行核酸提取和扩增。男性(n = 58)(50.43%,95%CI = 41.29%–59.57%)和女性(n = 57)(49.57%,95%置信区间 = 41.29%–59.57%)样本分布均匀(平均年龄 = 51.4 年;SD = ±16.5 年;范围 = 17–87 岁)。结果:基因型1b占主导地位(73%,95%CI = 64.89%–81.11%),其次是1a的高患病率(13.9%,95%CI = 7.58%-20.22%)和3种基因型(11.3%,95%CI = 5.51%-17.09%)。基因型2和4同样是最不流行的(0.9%,95%CI = −在基因型1b中,60.7%为女性,39.3%为男性;基因型1a中,女性占25%,男性占75%;在基因型3中,女性仅占7.7%,男性仅占92.3%。男性在基因型1a(75%)和3(92.3%)中最为普遍,而女性在基因型1b(60.7%)中最普遍。结论:在保加利亚东北部的慢性肝病患者中,HCV基因型lb是HCV基因型流行病学模式中的主要变异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Drug Assessment
Journal of Drug Assessment PHARMACOLOGY & PHARMACY-
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