Expression of FNDC5 in liver cancer tissues and its relationship with clinical parameters

中华普通外科杂志 Pub Date : 2020-02-25 DOI:10.3760/CMA.J.ISSN.1007-631X.2020.02.016

N. Tang, F. Huang, Deguo Zhang, Guangjun Shi

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Abstract

Objective To investigate the expression of FNDC5 in hepatocellular carcinoma (HCC) and its relationship with clinicopathological characteristics and prognosis of HCC patients. Methods Immunohistochemistry and qRT-PCR were used to detect the expression of FNDC5 in HCC tissues, and the relationship between its expression and clinicopathological parameters and prognosis. Results FNDC5 was mainly expressed in the cytoplasm of HCC cells, weakly expressed in the nucleus. Among the 30 liver cancer tissues, FNDC5 was weakly positive in 5, positive in 19, and strongly positive in 6 cases. QRT-PCR assay showed that FNDC5 was highly expressed in HCC tissues with vascular invasion.The incidence of vascular invasion in the high-expression of FNDC5 was 30% (9/30), which was significantly higher than that of the FNDC5 low-expression group[6.7% (2/30), ]and the difference was significant (χ2 =15.026, P 0.05). Conclusion FNDC5 level in the liver cancer tissues is closely related to the occurrence of vascular invasion. Key words: Carcinoma, hepatocellular; Neoplasm invasiveness

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FNDC5在癌症组织中的表达及其与临床参数的关系

目的探讨肝细胞癌（HCC）中FNDC5的表达及其与HCC患者临床病理特征和预后的关系。方法应用免疫组织化学和qRT-PCR方法检测FNDC5在HCC组织中的表达，以及其表达与临床病理参数和预后的关系。结果FNDC5主要在HCC细胞的细胞质中表达，在细胞核中表达较弱。30例癌症组织中，FNDC5弱阳性5例，阳性19例，强阳性6例。QRT-PCR检测显示FNDC5在有血管浸润的HCC组织中高表达。FNDC5高表达组的血管侵犯发生率为30%（9/30），明显高于低表达组的[6.7%（2/30）]，差异有显著性（x2=15.026，P＜0.05）。结论癌症组织中FNDC5水平与血管侵犯的发生密切相关。关键词：肝癌；肿瘤侵袭性

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中华普通外科杂志

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