In Vitro Cytotoxicity of Cyanuric Acid and Selected Derivatives

Abstract

Copyright 2018 by Dzhambazov B. This is an open-access article distributed under Creative Commons Attribution 4.0 International License (CC BY 4.0), which allows to copy, redistribute, remix, transform, and reproduce in any medium or format, even commercially, provided the original work is properly cited. 14 cc Original Research Original Research | Volume 3 | Number 1| Background Cyanuric acid and its derivatives belong to the group of s-triazines. They have wide industrial application, generally in the production of pesticides, bleaching agents and disinfectants. Recent reports showed significant negative effect of cyanuric acid in combination with melamine but low general cytotoxicity of cyanuric acid alone. However, evaluations of cyanuric acid toxicity against different human cell types using a panel of in vitro assays have not been performed. In addition, little is known about the cytotoxicity and potential antitumor effects of certain cyanuric acid derivatives, for example trichloroisocyanuric acid and 1,3,5-tris(2-hydroxyethyl) isocyanurate.