Interrelations between mental health, generic and thyroid-related quality of life in patients with Hashimoto’s thyroiditis receiving levothyroxine replacement

IF 1.8 Q3 PSYCHOLOGY, CLINICAL

Mediterranean Journal of Clinical Psychology Pub Date : 2021-08-08 DOI:10.13129/2282-1619/MJCP-3072

G. Martino, A. Caputo, C. Vicario, U. Feldt-Rasmussen, T. Watt, R. Vita, M. Quattropani, S. Benvenga

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引用次数: 3

Abstract

The assessment of health-related quality of life (QoL) in chronic conditions is considered as relevant, especially in patients with hypothyroidism where a high comorbidity with depressive and anxiety issues is reported. The present cross-sectional pilot study aims at: i) examining the correlation of thyroid-specific and generic measures of QoL in patients with Hashimoto’s Thyroiditis (HT); ii) investigating the associations of generic and thyroid-specific measures of QoL with depression and anxiety in patients with HT; iii) comparing generic and thyroid-specific measures of QoL in patients with HT versus controls. Twenty-one patients with serologically and/or ultrasonographically verified HT and sixteen controls with non-toxic goiter or post-surgical hypothyroidism were recruited for this study. Generic and disease-specific QoL were assessed by Health Survey Short Form-36 (SF-36) and Thyroid Patient Reported Outcome (ThyPRO) questionnaires, respectively, whereas depression and anxiety were measured through Beck Depression Inventory-second edition (BDI-II) and Hamilton Anxiety Rating Scale (HAM-A) questionnaires, respectively. Findings showed that ThyPRO and SF-36 scores were associated with each other only regarding the mental health domain, and that such QoL measures were consistently associated with depression levels but not with anxiety. Besides, no statistically significant difference was found between patients with HT and controls with regard to generic and thyroid-specific QoL. The present study suggests that generic and disease-specific measures of QoL can sufficiently assess the mental functioning domain and capture depressive symptoms, but only thyroid-specific measures (such as ThyPRO) can provide an accurate examination of physical aspects of QoL and the overall disease impact in patients’ lives. Besides, some methodological limitations should be taken into account in both using generic and disease-specific instruments with regard to their tendency to underestimate possible anxiety problems.

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接受左甲状腺素替代治疗的桥本甲状腺炎患者的心理健康、一般生活质量和甲状腺相关生活质量之间的相关性

慢性病患者的健康相关生活质量（QoL）评估被认为是相关的，尤其是在甲状腺功能减退症患者中，据报道，他们与抑郁和焦虑问题有很高的共病性。本横断面试点研究旨在：i）检查桥本甲状腺炎（HT）患者甲状腺特异性和一般性生活质量指标的相关性；ii）调查HT患者的一般性和甲状腺特异性生活质量指标与抑郁和焦虑的关系；iii）比较HT患者与对照组的一般性和甲状腺特异性生活质量指标。本研究招募了21名经血清学和/或超声检查证实患有HT的患者和16名患有无毒性甲状腺肿或术后甲状腺功能减退症的对照组。一般性和疾病特异性生活质量分别通过健康调查简表-36（SF-36）和甲状腺患者报告结果（ThyPRO）问卷进行评估，而抑郁和焦虑分别通过贝克抑郁量表第二版（BDI-II）和汉密尔顿焦虑评定量表（HAM-A）问卷进行测量。研究结果表明，ThyPRO和SF-36评分仅在心理健康领域相互关联，并且这种生活质量指标与抑郁水平一致，但与焦虑无关。此外，在一般性和甲状腺特异性生活质量方面，HT患者和对照组之间没有发现统计学上的显著差异。本研究表明，生活质量的通用和疾病特异性测量可以充分评估精神功能领域并捕捉抑郁症状，但只有甲状腺特异性测量（如ThyPRO）才能准确检查生活质量的身体方面和患者生活中的整体疾病影响。此外，在使用通用和疾病特异性工具时，应考虑到一些方法上的局限性，因为它们倾向于低估可能的焦虑问题。

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来源期刊

Mediterranean Journal of Clinical Psychology PSYCHOLOGY, CLINICAL-

CiteScore

4.10

自引率

53.80%

发文量

审稿时长

4 weeks

期刊介绍： The MJCP is an Open Access Peer-Reviewed International Journal in Clinical Psychology. MJCP accepts research related to innovative and important areas of clinical research: 1. Clinical studies related to Clinical Psychology, 2. Psychopathology and Psychotherapy; 3. Basic studies pertaining to clinical psychology field as experimental psychology, psychoneuroendocrinology and psychoanalysis; 4. Growing application of clinical techniques in clinical psychology, psychology of health, clinical approaches in projective methods; 5. Forensic psychology in clinical research; 6. Psychology of art and religion; 7. Advanced in basic and clinical research methodology including qualitative and quantitative research and new research findings.