Cross-Sectional Survey of Views on COVID-19 and Its Vaccines Among Pregnant Women

Abstract

Abstract Objective The objective of this study is to evaluate the acceptance of pregnant women with regards to coronavirus disease 2019 (COVID-19) vaccination during pregnancy and to identify any significant changes in their anxiety and knowledge on COVID-19 compared to our previous study. Methods This cross-sectional survey was performed in the antenatal clinics of United Christian Hospital and Tseung Kwan O Hospital of Hong Kong, China. Questionnaires were distributed to pregnant women for self-completion when attending follow-up from August to October 2021. Apart from basic demographic data, the questionnaire comprised of questions including knowledge on COVID-19 and its vaccines in pregnancy as well as attitudes and behaviors of pregnant women and their partners toward COVID-19. Continuous variables were analyzed by Student’s test and Levene’s test was used to confirm normal distribution and homogeneity of variance for continuous variables, whereas categorical variables were analyzed by the Chi-squared test or Fisher’s exact test as appropriate. A P value of <0.05 was considered to be statistically significant. Results A total of 816 completed questionnaires were included for analysis. Pregnant women were less worried about COVID-19 in the current survey as compared to the last survey (393/816, 48.2% vs. 518/623, 83.1%, P?

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孕妇对COVID-19及其疫苗的看法横断面调查

摘要目的本研究的目的是评估妊娠期孕妇对2019冠状病毒病(COVID-19)疫苗接种的接受程度，并确定与我们之前的研究相比，她们对COVID-19的焦虑和知识是否有显著变化。方法在香港基督教联合医院和将军澳医院产前门诊进行横断面调查。于2021年8月至10月参加随访时向孕妇发放问卷，供其自行填写。除了基本的人口统计数据外，调查问卷还包括孕妇对COVID-19及其疫苗的知识以及孕妇及其伴侣对COVID-19的态度和行为等问题。连续变量分析采用Student’s检验，连续变量采用Levene’s检验确认正态分布和方差齐性，分类变量分析采用卡方检验或Fisher精确检验。P值<0.05认为有统计学意义。结果共收集问卷816份进行分析。本次调查中孕妇对新冠肺炎的担忧程度低于上次调查(393/816,48.2%比518/623,83.1%，P < 0.001)。与上次调查相比，认为妊娠期更容易感染SARS-CoV-2的孕妇较少(265/816,32.5%比261/623,41.9%，P < 0.001)。他们对COVID-19疫苗存在巨大的知识差距和担忧。近一半的参与者认为孕妇不能接种COVID-19疫苗(402/816,49.3%)，对胎儿不安全(365/816,44.7%)。约三分之一的妇女认为，与一般人群相比，她们更容易出现COVID-19疫苗的副作用和并发症(312/816,38.2%)，并且没有认识到母体接种COVID-19疫苗可以影响抗体向胎儿的转移，从而促进产后被动免疫(295/816,36.2%)。未接种疫苗者占绝大多数(715/816,87.6%)，仅有(12/715)1.7%的孕妇考虑在孕期接种疫苗。结论尽管当地和国际上都建议孕妇接种疫苗，但妊娠期间COVID-19疫苗的接种率仍然极低。应努力有效地提供有关怀孕期间COVID-19疫苗安全性和益处的信息。迫切需要提高孕妇的疫苗接种率，以避免与COVID-19相关的过度不良妊娠结局。

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