De-escalation Strategies in Human Papilloma Virus-Positive Oropharyngeal Cancer

Pub Date : 2020-07-01 DOI:10.4103/jhnps.jhnps_29_20
Vishal Gupta
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Abstract

Human papilloma virus (HPV) is now attributable to most of the oropharyngeal squamous cell cancers (OPSCCs) occurring in western world. The HPV-associated OPSCC effect younger, otherwise healthy population and is typically associated with better outcome. Traditional treatment strategies, while successful, are associated with significant long-term morbidity and poorer quality of life. This has led to various trials and investigations to de-escalate the treatment in this patient population while maintaining excellent outcome. The objective of this review is to discuss various de-escalation strategies and trials.
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人乳头状瘤病毒阳性口咽癌的降级策略
人类乳头状瘤病毒(HPV)可归因于西方世界发生的大多数口咽鳞状细胞癌(OPSCCs)。HPV相关的OPSCC影响年轻、健康的人群,通常与更好的结果相关。传统的治疗策略虽然成功,但会导致严重的长期发病率和较差的生活质量。这导致了各种试验和调查,以降低该患者群体的治疗水平,同时保持良好的结果。本次审查的目的是讨论各种缓和策略和审判。
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