Chronic Hypertension During the First Trimester of Pregnancy: What is New About the Use of Angiotensin-Converting Enzyme Inhibitors?

Abstract

Cardiovascular diseases are a major cause of maternal mortality and morbidity worldwide, including developed countries [1]. The first-line drug to treat hypertension in pregnant women is methyldopa, which is an α2-adrenergic agent that has shown maternal and fetal safety and efficacy. However, methyldopa is not effective in all cases, and sometimes it is important to consider other pharmacological agents [1,2].