Research status of granulocyte transfusions

国际输血及血液学杂志 Pub Date : 2019-09-20 DOI:10.3760/CMA.J.ISSN.1673-419X.2019.05.003

Mengying Zhang, Huaquan Wang

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引用次数: 0

Abstract

Neutrophils are one of the most important cells in the body against bacterial and fungal infections. Patients with acute leukemia who received radiotherapy, chemotherapy or hematopoietic stem cell transplantation (HSCT), and with severe aplastic anemia (SAA), can occur with severe neutropenia that lasts longer, during which severe bacterial and fungal infections can occur. Despite the use of broad-spectrum antibacterial agents and granulocyte colony-stimulating factor (G-CSF), severe infections during neutropenia still lead to prolonged hospital stay, organ damage, and even death of patients. The recovery of bone marrow granulocyte hematopoiesis is the key to successful infection control. For patients with severe infections of granulocytopenia, especially agranulocytosis, granulocyte transfusions is a means of adjuvant therapy. In order to understand the role and indications of granulocyte transfusions, the article intends to introduce the collection technology of granulocyte, therapeutic effect and adverse reactions of granulocyte transfusions. Key words: Neutropenia; Agranulocytosis; Granulocyte colony-stimulating factors; Infection; Granulocyte transfusions; Neutrophil dysfunction

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粒细胞输注的研究现状

中性粒细胞是人体抵抗细菌和真菌感染的最重要的细胞之一。急性白血病患者接受放疗、化疗或造血干细胞移植(HSCT)，并伴有严重再生障碍性贫血(SAA)，可发生持续较长时间的严重中性粒细胞减少，期间可发生严重的细菌和真菌感染。尽管使用了广谱抗菌药物和粒细胞集落刺激因子(G-CSF)，但中性粒细胞减少期间的严重感染仍会导致患者住院时间延长、器官损伤，甚至死亡。骨髓粒细胞造血功能的恢复是感染控制成功的关键。对于严重感染的粒细胞减少症，特别是粒细胞缺乏症患者，粒细胞输注是辅助治疗的一种手段。为了解粒细胞输注的作用及适应证，本文拟介绍粒细胞的采集技术、输注的治疗效果及不良反应。关键词:中性粒细胞减少症;粒细胞缺乏症;粒细胞集落刺激因子;感染;粒细胞输血;嗜中性粒细胞功能障碍

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来源期刊

国际输血及血液学杂志

自引率

0.00%

发文量

10610

期刊介绍： The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.