Effect of vitamin D intervention on the outcome of glucose metabolism in patients with impaired glucose regulation

Q4 Nursing

中华临床营养杂志 Pub Date : 2019-12-30 DOI:10.3760/CMA.J.ISSN.1674-635X.2019.06.004

Jingjing Lu, Yeqing Liu, Jie Zhang, Pingping Lou, Yan Liu

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引用次数: 1

Abstract

Objective To explore the intervention effect of low-dose vitamin D on glucose metabolism of patients with impaired glucose regulation. Methods A total of 196 subjects receiving oral glucose tolerance test were enrolled in this study, including individuals with normal glucose tolerance (NGT group, n=67) and individuals with impaired glucose regulation (IGR group, n=129). The IGR group was divided into intervention group (n=64)and non-intervention group (n=65) according to vitamin D intervention (for 1 year) performed or not. Clinical data and biochemical parameters were collected. Results The level of serum 25(OH)D3 was significantly lower in the IGR group than that of normal control group (P<0.05). After 1 year of low-dose vitamin D intervention, insulin sensitivity increased and insulin resistance decreased in the intervention group as compared with non-intervention group. Diabetes developed less frequently in the intervention group (25 of 64 [39.1%]) compared with non-intervention group (30 of 65 [46.2%]). But there was no significant different in diabetes prevalence between the two groups. Conclusions Vitamin D intervention can improve insulin sensitivity and reduce insulin resistance in patients with impaired glucose regulation. Low dose vitamin D can improve the abnormal glucose metabolism outcome in patients with impaired glucose regulation. Key words: vitamin D; 25(OH)D3; type 2 diabetes mellitus; insulin secretion

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维生素D干预对糖调节受损患者糖代谢结果的影响

目的探讨低剂量维生素D对糖调节受损患者糖代谢的干预作用。方法本研究共纳入196名接受口服糖耐量试验的受试者，包括糖耐量正常的个体（NGT组，n=67）和糖调节受损的个体（IGR组，n=129）。IGR组根据是否进行维生素D干预（1年）分为干预组（n=64）和非干预组（n=65）。收集临床数据和生化参数。结果IGR组血清25（OH）D3水平明显低于正常对照组（P＜0.05），低剂量维生素D干预1年后，干预组胰岛素敏感性升高，胰岛素抵抗下降。干预组（25/64[39.1%]）的糖尿病发生率低于非干预组（30/65[46.2%]）。但两组的糖尿病患病率没有显著差异。结论维生素D干预可改善糖调节受损患者的胰岛素敏感性，降低胰岛素抵抗。低剂量维生素D可以改善葡萄糖调节受损患者的异常葡萄糖代谢结果。关键词：维生素D；25（OH）D3；2型糖尿病；胰岛素分泌

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来源期刊

中华临床营养杂志 Nursing-Nutrition and Dietetics

CiteScore

0.20

自引率

0.00%

发文量

2282

期刊介绍： The Chinese Journal of Clinical Nutrition was founded in 1993. It is the first professional academic journal (bimonthly) in my country co-sponsored by the Chinese Medical Association and the Chinese Academy of Medical Sciences to disseminate information on clinical nutrition support, nutrient metabolism, the impact of nutrition support on outcomes and "cost-effectiveness", as well as translational medicine and nutrition research. It is also a professional journal of the Chinese Medical Association's Parenteral and Enteral Nutrition Branch. The purpose of the Chinese Journal of Clinical Nutrition is to promote the rapid dissemination of knowledge on nutrient metabolism and the rational application of parenteral and enteral nutrition, focusing on the combination of multidisciplinary and multi-regional field investigations and clinical research. It mainly reports on nutritional risk screening related to the indications of parenteral and enteral nutrition support, "cost-effectiveness" research on nutritional drugs, consensus on clinical nutrition, guidelines, expert reviews, randomized controlled studies, cohort studies, glycoprotein and other nutrient metabolism research, systematic evaluation of clinical research, evidence-based case reports, special reviews, case reports and clinical experience exchanges, etc., and has a special column on new technologies related to the field of clinical nutrition and their clinical applications.