Prognostic assessment in COPD patients: BODE index and the health-related quality of life

K. Sharma, Avinash Jain, R. Takhar, Dps Sudan, V. Goyal, N. Goel, Vikram Singh
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引用次数: 2

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a spreading epidemic of a debilitating disease impairing the health-related quality of life (HRQoL) of the patients. This study was conducted to identify the relationship between BODE (body mass index, obstruction, dyspnea, exercise capacity) index and the St George’s Respiratory Questionnaire (SGRQ) and to test the predictive value of both tools against survival. Methods: Open cohort study of 120 COPD patients were followed up to 1 year. At the time of the inclusion, clinical data, forced spirometry, 6-minute walking distance, BODE index, and SGRQ were determined. Vital status and cause of death were documented at the end of follow-up. Results: The cohort’s mean score of age, SGRQ Total (SGRQ_Tot), and BODE index was 57.82 ± 7.58, 44.77 ± 13.81, and 3.04 ± 2.06, respectively. The correlation between SGRQ_Tot and BODE index was good (r = 0.611, P < 0.001). Regression analysis determined age, BODE, comorbidity index, and activity component of SGRQ (SGRQ_A) as predictors of mortality. The area under the curve for the BODE index was 0.801 vs. 0.692 for the SGRQ_A score indicating BODE score as best predictor of mortality. The best cut-off value for predicting mortality was 4.5 for BODE index and 62.5 for SGRQ_A score. Conclusion: Evaluation of HRQoL is an important entity for improving overall disease outcome of COPD.
COPD患者的预后评估:BODE指数与健康相关的生活质量
背景:慢性阻塞性肺病(COPD)是一种正在传播的疾病,它会损害患者的健康生活质量。本研究旨在确定BODE(体重指数、阻塞、呼吸困难、运动能力)指数与圣乔治呼吸问卷(SGRQ)之间的关系,并测试这两种工具对生存的预测价值。方法:对120例COPD患者进行开放性队列研究,随访1年。纳入时,测定临床数据、强迫肺活量测定法、6分钟步行距离、BODE指数和SGRQ。随访结束时记录生命状态和死亡原因。结果:该队列的年龄、SGRQ总分(SGRQ_Tot)和BODE指数的平均得分为57.82 ± 7.58,44.77 ± 13.81和3.04 ± 分别为2.06。SGRQ_Tot与BODE指数相关性良好(r = 0.611,P<0.001)。回归分析确定年龄、BODE、合并症指数和SGRQ的活性成分(SGRQ_A)是死亡率的预测因素。BODE指数的曲线下面积为0.801,SGRQ_A评分为0.692,表明BODE评分是死亡率的最佳预测指标。BODE指数和SGRQ_A评分预测死亡率的最佳截止值分别为4.5和62.5。结论:HRQoL评价是改善COPD患者整体疾病转归的重要指标。
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