A Comprehensive Review on Therapeutic Potentials of Natural Cyclic Peptides

IF 0.8 Q4 NUTRITION & DIETETICS
Renu Saharan, Suresh Kumar, S. Khokra, Sunil Singh, A. Tiwari, V. Tiwari, B. Sahoo, Manish Kumar
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引用次数: 1

Abstract

Cyclic peptides have emerged as a promising class of organic compounds that possess polypeptide chains with a cyclic ring structure. There is a circular sequence of bonds in which the ring structure is formed via linkage between one end of the peptide bond and the other end with an amide bond or any other chemically stable bonds like ether, thioether, lactone, and disulfide. Generally, the cyclic peptides are isolated from natural resources like invertebrate animals, micro-organisms of marine habitats, and higher plants. These cyclic peptides possess unique structures with diverse pharmacological activities. Now a day, cyclic peptides possess superior therapeutic value due to several reasons such as greater resistance to enzymatic degradation (in vivo) and higher bio-availability. Some of these cyclic peptides are rich in leucine, proline while some have other amino acids as their major constituents. Numerous novel cyclic peptides isolated from natural sources are successfully developed as bioactive products. Recently, cyclic peptides derived from natural resources have attracted attention for exploring their numerous beneficial effects. Moreover, it is reported that natural cyclic peptides exhibit various therapeutic activities like an anthelmintic, ACE inhibitor, anti-tumor, microtubule inhibitor, anti-fungal, anti-malarial, and platelet aggregation inhibiting activity. In this review, various cyclic peptides are reported with structures and biological activities that are isolated from various natural sources. The natural cyclic peptides possess a wide spectrum of biological activities and can become a drug of the future for replacing the existing drugs which develop resistance
天然环肽的治疗潜力综述
环肽是一类具有环状结构的多肽链的有机化合物。有一个圆形的键序列,其中环结构是通过肽键的一端与酰胺键或其他化学上稳定的键如醚、硫醚、内酯和二硫键的另一端连接而形成的。一般来说,环状肽是从自然资源中分离出来的,如无脊椎动物、海洋栖息地的微生物和高等植物。这些环肽具有独特的结构和不同的药理活性。如今,由于环肽具有更强的抗酶降解(体内)和更高的生物利用度等原因,环肽具有优越的治疗价值。这些环肽有的富含亮氨酸、脯氨酸,有的以其他氨基酸为主要成分。许多从天然来源分离的新型环肽被成功地开发为生物活性产品。近年来,从天然资源中提取的环肽因其多种有益作用而备受关注。此外,据报道,天然环肽具有多种治疗活性,如驱虫药、ACE抑制剂、抗肿瘤、微管抑制剂、抗真菌、抗疟疾和血小板聚集抑制活性。本文综述了从各种天然来源中分离出的具有结构和生物活性的环肽。天然环肽具有广泛的生物活性,可以成为替代现有耐药药物的未来药物
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来源期刊
Current Nutrition & Food Science
Current Nutrition & Food Science NUTRITION & DIETETICS-
CiteScore
2.00
自引率
0.00%
发文量
144
期刊介绍: Current Nutrition & Food Science publishes frontier reviews on all the latest advances on basic and clinical nutrition and food sciences. The journal aims to publish the highest quality review articles dedicated to research in the field. The journal is essential reading for all nutrition and food scientists.
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