Ultrasound-based surface sampling in immersion for mass spectrometry

IF 2.7 3区物理与天体物理 Q2 PHYSICS, APPLIED

Journal of Applied Physics Pub Date : 2023-09-08 DOI:10.1063/5.0157705

Tom Sillanpää, J. Hyvönen, J. Mäkinen, Axi Holmström, Topi Pudas, Petri Lassila, Riikka Lepistö, A. Kuronen, T. Kotiaho, E. Hæggström, A. Salmi

引用次数: 1

Abstract

We present a surface sampling method for the chemical analysis of liquid-immersed solid samples. Liquid immersion allows samples to be kept in a hydrated state. We employed cavitation generated by high-intensity focused ultrasound for localized material removal. The appropriate transducer–sample distance was determined using the actuating ultrasound transducer prior to sampling, allowing sonication in focus despite surface height variation. We demonstrate the proposed surface sampling method on water-submerged glass cover slides painted with permanent markers, achieving sampling with tunable spot size down to 500 μm. The removed and collected material was transferred for chemical analysis by electrospray ionization mass spectrometry, which showed mass peaks characteristic to the permanent markers.

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基于超声波的质谱浸没表面采样

提出了一种表面取样法，用于液浸固体样品的化学分析。液体浸泡使样品保持在水合状态。我们利用高强度聚焦超声产生的空化进行局部材料去除。在采样之前，使用驱动超声换能器确定合适的换能器-样品距离，允许在表面高度变化的情况下聚焦超声。我们在涂有永久标记的水浸玻璃盖玻片上演示了所提出的表面采样方法，实现了采样点尺寸可调至500 μm的采样。用电喷雾电离质谱法对去除和收集的物质进行化学分析，发现永久标记物具有一定的质量峰特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Applied Physics 物理-物理：应用

CiteScore

5.40

自引率

9.40%

发文量

1534

审稿时长

2.3 months

期刊介绍： The Journal of Applied Physics (JAP) is an influential international journal publishing significant new experimental and theoretical results of applied physics research. Topics covered in JAP are diverse and reflect the most current applied physics research, including: Dielectrics, ferroelectrics, and multiferroics- Electrical discharges, plasmas, and plasma-surface interactions- Emerging, interdisciplinary, and other fields of applied physics- Magnetism, spintronics, and superconductivity- Organic-Inorganic systems, including organic electronics- Photonics, plasmonics, photovoltaics, lasers, optical materials, and phenomena- Physics of devices and sensors- Physics of materials, including electrical, thermal, mechanical and other properties- Physics of matter under extreme conditions- Physics of nanoscale and low-dimensional systems, including atomic and quantum phenomena- Physics of semiconductors- Soft matter, fluids, and biophysics- Thin films, interfaces, and surfaces