Comparing Vitamin D and Uterine Leiomyoma Association to VDR Knock-Out Mouse

Abstract

Uterine leiomyoma is common women health issue at reproductive age. The vitamin D and it’s receptor deficiency are associated with UL in African-American patients at reproductive age. This association are not strong enough to be supported by VDR knock-out animal model phenotype, due to lack of spontaneous UL development. Here, we are trying to emphasize on the fact that VDR KO mice phenotype reveal predisposition to malignancy diet dependent to lead to tumor mass induction.