Research status of nicotine-aggravating the choroidal neovascularization formation in wet age-related macular degeneration

Q4 Medicine

中华眼底病杂志 Pub Date : 2020-04-25 DOI:10.3760/CMA.J.CN511434-20180704-00226

Yajun Gong, Kun-bei Lai, C. Jin

引用次数: 0

Abstract

Choroidal neovascularization is the leading causes of central vision loss in wet age-related macular degeneration (wAMD) patients. Smoking not only aggravates the incidence and severity of the choroidal neovascularization of wAMD, but also affects the clinical treatment, making the prognosis worse. Nicotine, as an important harmful substance in tobacco, is an easily addictive and highly toxic alkaloid. Animal experiments and clinical studies have confirmed that nicotine can aggravate wAMD by mediating angiogenesis through nicotinic acetylcholine receptor, bone marrow blasts, inflammation, complement system, etc. Therefore, in order to early take appropriate intervention measures to prevent and delay the development, we should actively explore the exact pathogenesis by which nicotine aggravates the choroidal neovascularization. Key words: Wet macular degeneration/etiology; Choroidal neovascularization/etiology; Nicotine; Review

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尼古丁加重湿性年龄相关性黄斑变性脉络膜新生血管形成的研究现状

脉络膜新生血管是湿性年龄相关性黄斑变性（wAMD）患者中心视力丧失的主要原因。吸烟不仅加重了wAMD脉络膜新生血管的发生率和严重程度，而且影响了临床治疗，使预后恶化。尼古丁是烟草中一种重要的有害物质，是一种易成瘾、高毒的生物碱。动物实验和临床研究已经证实，尼古丁可以通过烟碱乙酰胆碱受体、骨髓母细胞、炎症、补体系统等介导血管生成，从而加重wAMD。因此，为了及早采取适当的干预措施来预防和延缓其发展，我们应该积极探索尼古丁加重脉络膜新生血管的确切发病机制。关键词：湿性黄斑变性/病因；脉络膜新生血管形成/病因；尼古丁；审查

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来源期刊

中华眼底病杂志 Medicine-Ophthalmology

CiteScore

0.40

自引率

0.00%

发文量

5383

期刊介绍： Chinese Journal of Ocular Fundus Diseases is the only scientific journal in my country that focuses on reporting fundus diseases. Its purpose is to combine clinical and basic research, and to give equal importance to improvement and popularization. It comprehensively reflects the leading clinical and basic research results of fundus disease disciplines in my country; cultivates professional talents in fundus disease, promotes the development of fundus disease disciplines in my country; and promotes academic exchanges on fundus disease at home and abroad. The coverage includes clinical and basic research results of posterior segment diseases such as retina, uveal tract, vitreous body, visual pathway, and internal eye diseases related to systemic diseases. The readers are medical workers and researchers related to clinical and basic research of fundus diseases. According to the journal retrieval report of the Chinese Institute of Scientific and Technological Information, the comprehensive ranking impact factor and total citation frequency of the Chinese Journal of Ocular Fundus Diseases have been among the best in the disciplines of ophthalmology, otolaryngology, and ophthalmology in my country for many years. The papers published have been included in many important databases at home and abroad, such as Scopus, Peking University Core, and China Science Citation Database (CSCD).