Vanillic acid prevents interferon-alpha and cyclosporine A-induced depressant-like behavior in mice

IF 0.7 Q4 PHARMACOLOGY & PHARMACY

Journal of Reports in Pharmaceutical Sciences Pub Date : 2022-01-01 DOI:10.4103/jrptps.JRPTPS_82_21

Omid Hajhashemi, A. Mesripour, V. Hajhashemi

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引用次数: 3

Abstract

Background: Interferon-alpha (IFN-α) is a useful therapy for some types of cancers and viral infections. Cyclosporine A (CSA) is an immunosuppressant drug used to reduce the risk of graft rejection. Chronic use of IFN-α and CSA are related to psychological symptoms such as depression. Vanillic acid (VA) is a naturally occurring flavoring substance with antidepressant potential. The aim of this study was to evaluate the effect of VA on depression caused by these two drugs in a mice model. Materials and Methods: Male Swiss mice (25–30 g) were used. Depression was induced by IFN-α 1600000 IU/kg, sc for six days, or CSA20 mg/kg, ip for 3 days as VA 25 mg/kg, and pretreatment was ip injected. After evaluating the locomotor activity, depression was assessed by forced swimming test (FST) and sucrose preference (SP) test. Results: The selected treatments did not cause significant changes in the locomotor activity. IFN-α significantly increased the immobility time during FST (184.5 ± 12.9 s vs. vehicle 107.1 ± 11.4s) indicating depressive-like effect, and VA pretreatment reversed it (94.8 ± 17.8 s vs. IFN-α), SP increased to 76%. CSA also increased the immobility time during FST (160.3 ± 3.4 s vs. vehicle 113.2 ± 7.6 s; P < 0.05), VA pretreatment reduced it (81.8 ± 16.9 s, vs. cyclosporine; P < 0.001), and SP increased from 38% to 75%. SP results were in agreement with FST results. Conclusion: VA showed useful effect against IFN-α and cyclosporine-induced depression in mice. Further clinical studies regarding VA antidepressant effect in patients receiving IFN-α or CSA are warranted.

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香草酸可预防干扰素α和环孢素a诱导的小鼠抑郁样行为

背景：干扰素-α（IFN-α）对某些类型的癌症和病毒感染是一种有用的治疗方法。环孢菌素A（CSA）是一种免疫抑制剂，用于降低移植物排斥反应的风险。长期使用IFN-α和CSA与抑郁症等心理症状有关。香草酸（VA）是一种天然存在的具有抗抑郁潜力的调味物质。本研究的目的是在小鼠模型中评估VA对这两种药物引起的抑郁症的影响。材料和方法：雄性瑞士小鼠（25-30 g）使用。IFN-α1600000 IU/kg，sc 6天，或CSA20诱导抑郁症 mg/kg，ip 3天，作为VA 25 mg/kg，ip注射预处理。在评估运动活动后，通过强迫游泳试验（FST）和蔗糖偏好试验（SP）来评估抑郁。结果：所选择的治疗没有引起运动活动的显著变化。IFN-α显著增加FST期间的不动时间（184.5 ± 12.9 s与车辆107.1 ± 11.4s）表示抑郁样作用，VA预处理逆转了这种作用（94.8 ± 17.8 与IFN-α相比），SP增加到76%。CSA还增加了FST期间的不动时间（160.3 ± 3.4 s与车辆113.2 ± 7.6 sP＜0.05），VA预处理使其降低（81.8 ± 16.9 s、 vs.环孢菌素；P＜0.001），SP从38%增加到75%。SP结果与FST结果一致。结论：VA对IFN-α和环孢菌素诱导的小鼠抑郁有一定的抑制作用。有必要对接受IFN-α或CSA治疗的VA患者的抗抑郁作用进行进一步的临床研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Reports in Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： The Journal of Reports in Pharmaceutical Sciences(JRPS) is a biannually peer-reviewed multi-disciplinary pharmaceutical publication to serve as a means for scientific information exchange in the international pharmaceutical forum. It accepts novel findings that contribute to advancement of scientific knowledge in pharmaceutical fields that not published or under consideration for publication anywhere else for publication in JRPS as original research article. all aspects of pharmaceutical sciences consist of medicinal chemistry, molecular modeling, drug design, pharmaceutics, biopharmacy, pharmaceutical nanotechnology, pharmacognosy, natural products, pharmaceutical biotechnology, pharmacology, toxicology and clinical pharmacy.