Interleukin-6-634 G/C gene polymorphisms in recurrent pregnancy loss among Egyptian women: Does it make a difference?

IF 0.8 Q4 GENETICS & HEREDITY

Meta Gene Pub Date : 2021-12-01 DOI:10.1016/j.mgene.2021.100955

Doaa A. Abo-alella , Iman M. Ouda , Rasha R. Abd Elhady , Alia A. El Shahawy

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引用次数: 1

Abstract

The balance between maternal immune responses and tolerance is considered as especially critical issue in the dilemma of recurrent pregnancy loss (RPL). Interleukin 6 (IL6) plays a fundamental role in fetal implantation and maintenance of pregnancy. This study aimed to explore the association between IL6–634 G/C gene polymorphisms and their serum levels in females with RPL. An observational case-control study involved 102 controls and 102 cases with RPL. Genotyping of IL6 polymorphism −634 G/C was done with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and their serum levels were measured. There was no statistically significant difference between controls and RPL cases as regard serum IL6 level. The percentage of distribution for allele G was 88.7%, and 78% in controls and cases respectively (p = 0.005). The risk of RPL was decreased by 60% in carriers of allele G (OR = 0.4, 95%CI: 0.2–0.8, p = 0.003). Besides, the homozygote genotype GG (OR = 0.5, 95%CI: 0.28–0.95, p = 0.031), was linked with decreased risk for RPL. The homozygous GG genotype and G allele were associated with decreased risk of RPL in Egyptian females.

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白细胞介素-6-634 G/C基因多态性在埃及妇女复发性妊娠丢失:它有区别吗?

在复发性妊娠丢失(RPL)的困境中，母体免疫反应和耐受之间的平衡被认为是一个特别关键的问题。白细胞介素6 (IL6)在胎儿着床和妊娠维持中起着重要作用。本研究旨在探讨il - 6 - 634 G/C基因多态性与RPL女性血清水平的关系。一项观察性病例-对照研究包括102例对照和102例RPL患者。采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)对IL6多态性−634 G/C进行基因分型，并测定血清水平。对照组与RPL患者血清il - 6水平差异无统计学意义。G等位基因在对照组和病例中的分布比例分别为88.7%和78% (p = 0.005)。携带等位基因G的RPL风险降低60% (OR = 0.4, 95%CI: 0.2 ~ 0.8, p = 0.003)。此外，纯合子基因型GG (OR = 0.5, 95%CI: 0.28-0.95, p = 0.031)与RPL风险降低相关。纯合子GG基因型和G等位基因与埃及女性RPL风险降低相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Meta Gene Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： Meta Gene publishes meta-analysis, polymorphism and population study papers that are relevant to both human and non-human species. Examples include but are not limited to: (Relevant to human specimens): 1Meta-Analysis Papers - statistical reviews of the published literature of human genetic variation (typically linked to medical conditionals and/or congenital diseases) 2Genome Wide Association Studies (GWAS) - examination of large patient cohorts to identify common genetic factors that influence health and disease 3Human Genetics Papers - original studies describing new data on genetic variation in smaller patient populations 4Genetic Case Reports - short communications describing novel and in formative genetic mutations or chromosomal aberrations (e.g., probands) in very small demographic groups (e.g., family or unique ethnic group). (Relevant to non-human specimens): 1Small Genome Papers - Analysis of genetic variation in organelle genomes (e.g., mitochondrial DNA) 2Microbiota Papers - Analysis of microbiological variation through analysis of DNA sequencing in different biological environments 3Ecological Diversity Papers - Geographical distribution of genetic diversity of zoological or botanical species.