Urinary Advanced Oxidation Protein Product: A Potential Oxidative Damage Marker for Cancer

IF 0.2 4区医学 Q4 MEDICINE, GENERAL & INTERNAL

West Indian Medical Journal Pub Date : 2018-03-21 DOI:10.7727/WIMJ.2012.324

S. Chandramathi, K. Suresh, Z. B. Anita, U. Kuppusamy

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引用次数: 1

Abstract

Objective: Oxidative stress has been implicated in the pathophysiology of various life threatening diseases namely cancer, cardiovascular disease and diabetes. This study aims to compare the severity of oxidative damage in cancer and some factors that may influence the levels of urinary oxidative biomarkers. The factors were sample collection period, cancer stages and lifestyle disease conditions (which are known to be associated with oxidative stress) such as diabetes with and without hypertension. Methods: The effects of the above mentioned factors on the levels of urinary advanced oxidation protein product (AOPP) and other oxidative indices such as hydrogen peroxide (H2O2), malondialdehyde (MDA) and ferric-reducing antioxidant power (FRAP) were evaluated according to well-established methods. Results: The period of sample collection did not show any significant difference in the parameters tested. The levels of oxidative stress in breast and colorectal cancer patients that generally increased with the cancer stages showed that cancer progression correlates with high oxidative damage. Comparison between diabetes with and without hypertension did not give any significant difference in the parameters tested. Among all the four oxidative indices, the level of AOPP in breast, colorectal and other types of cancers were significantly higher compared to diabetes with or without hypertension. Conclusions: The oxidative damage to protein is significantly higher in cancer and may potentially serve as a non-invasive oxidative biomarker for this disease.

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尿晚期氧化蛋白产物：癌症潜在的氧化损伤标志物

目的:氧化应激参与多种危及生命的疾病如癌症、心血管疾病和糖尿病的病理生理。本研究旨在比较癌症中氧化损伤的严重程度以及可能影响尿液氧化生物标志物水平的一些因素。这些因素包括样本收集期、癌症分期和生活方式疾病状况(已知与氧化应激有关)，如伴有或不伴有高血压的糖尿病。方法:按既定方法评价上述因素对尿中晚期氧化蛋白产物(AOPP)水平及过氧化氢(H2O2)、丙二醛(MDA)、铁还原抗氧化能力(FRAP)等氧化指标的影响。结果:样品采集周期在所测参数上无显著差异。乳腺癌和结直肠癌患者的氧化应激水平通常随着癌症分期的增加而增加，这表明癌症的进展与高氧化损伤有关。合并高血压和不合并高血压的糖尿病之间的比较在测试参数上没有任何显著差异。四项氧化指标中，AOPP在乳腺癌、结直肠癌等类型肿瘤中的水平均明显高于合并或不合并高血压的糖尿病患者。结论:蛋白质的氧化损伤在癌症中明显更高，可能作为该疾病的非侵入性氧化生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

West Indian Medical Journal 医学-医学：内科

CiteScore

0.20

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： The Journal is international in scope, with author and editorial contributions from across the globe. The focus is on clinical and epidemiological aspects of tropical and infectious diseases, new and re-emerging infections, chronic non-communicable diseases, and medical conditions prevalent in the Latin America-Caribbean region, and of significance to global health, especially in developing countries. The Journal covers all medical disciplines, as well as basic and translational research elucidating the pathophysiologic basis of diseases or focussing on new therapeutic approaches, and publishes original scientific research, reviews, case reports, brief communications, letters, commentaries and medical images. The Journal publishes four to six issues and four supplements annually. English is the language of publication but Abstracts are also duplicated in Spanish. Most of the articles are submitted at the authors’ initiative, but some are solicited by the Editor-in-Chief. Unless expressly stated, the Editorial Board does not accept responsibility for authors’ opinions. All papers on submission are reviewed by a subcommittee. Those deemed worthy for review are sent to two or three reviewers (one of the three might be a statistician if necessary). The returned papers with reviewer comments are reviewed by the Editor-in-Chief. Papers may be rejected, accepted or sent back to authors for revision. Resubmitted papers from authors are reviewed by the Editor-in-Chief and may be sent back to reviewers or a final decision made by Editor-in-Chief. The decision of the Editorial Board is final with regards to rejected articles. Rejected articles will not be returned to the authors. The editorial subcommittee has the right to return sub-standard manuscripts to the authors, rather than passing them on to the reviewers. This implies outright rejection of the manuscript.