Risk Factors of Parkinson’s Disease: A Case-Control Study in Moroccan Patients

IF 0.4 Q4 NEUROSCIENCES

Archives of Neuroscience Pub Date : 2022-08-09 DOI:10.5812/ans-126351

A. Achbani, Abdellatif Ait Ougjij, S. Ait wahmane, H. Sine, A. Kharbach, Youssef Bouchriti, A. Belmouden, M. Nejmeddine

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引用次数: 1

Abstract

Background: Parkinson’s disease (PD) remains a significant health concern in Morocco. Multivariate analysis was not used in any study to evaluate the role of various factors that contributed to the onset of the disease. Objectives: This study investigates the role of family, environmental, and professional factors in PD development. Methods: The present study is an age-matched case-control study with risk estimation based on odds ratios (OR) with a 95% confidence interval (CI). In total, 180 cases were matched with 360 controls. Results: The average age of participants was 68.3 ± 11.2 years. Adjusted logistic regression analysis showed that the family history of PD (ORa = 7.19, CI 95% 3.41 - 15.13), male sex (ORa = 1.92, CI 95% 1.16 - 3.16), spring water consumption (ORa = 3.31, CI 95% 2.05 - 5.34), drug use (ORa = 2.12, CI 95% 1.33 - 3.38), a history of head injury (ORa = 3.38, CI 95% 1.16 - 9.83) and non - consumption of coffee (ORa = 3.04, CI 95%1.56 - 5.90) were significantly associated with the onset of the disease. In a univariate analysis, well water consumption was observed as a significant risk factor but could not be shown to be significant in a multivariate analysis. Previous work on a farm (ORa = 0.30, CI 95% 0.16 - 0.54) and history of general anesthesia (ORa = 0.47, CI 95% 0.27 - 0.83) were inversely associated with PD risk. No statistical significance was observed in the data on occupational exposure and disease risk, although there was a 30% decrease in risk for the service occupations (ORa = 0.05, CI 95% 0.01 - 0.18). Conclusions: As a result, further research is needed to determine additional risk factors.

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帕金森病的危险因素：摩洛哥患者的病例对照研究

背景:帕金森病(PD)在摩洛哥仍然是一个重要的健康问题。在任何研究中都没有使用多变量分析来评估导致疾病发病的各种因素的作用。目的:探讨家庭、环境和职业因素在帕金森病发展中的作用。方法:本研究是一项年龄匹配的病例对照研究，风险估计基于优势比(OR)， 95%置信区间(CI)。总共180例与360例对照。结果:患者平均年龄68.3±11.2岁。调整逻辑回归分析表明,PD的家族史(ORa = 7.19, 95% CI 3.41 - 15.13),男性(ORa = 1.92, 95% CI 1.16 - 3.16),泉水消费(ORa = 3.31, 95% CI 2.05 - 5.34),吸毒(ORa = 2.12, 95% CI 1.33 - 3.38),头部受伤的历史(ORa = 3.38, 95% CI 1.16 - 9.83)和非饮用咖啡(ORa = 3.04, 95% CI 1.56 - 5.90)明显与疾病的发病有关。在单变量分析中，井水消耗被观察到是一个重要的危险因素，但在多变量分析中不能显示出显著性。以前在农场工作(ORa = 0.30, CI 95% 0.16 - 0.54)和全身麻醉史(ORa = 0.47, CI 95% 0.27 - 0.83)与PD风险呈负相关。职业暴露和疾病风险数据无统计学意义，但服务性职业的风险降低了30% (ORa = 0.05, CI 95% 0.01 - 0.18)。结论:因此，需要进一步研究以确定其他危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Neuroscience NEUROSCIENCES-

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期刊介绍： Archives of neuroscience is a clinical and basic journal which is informative to all practitioners like Neurosurgeons, Neurologists, Psychiatrists, Neuroscientists. It is the official journal of Brain and Spinal Injury Research Center. The Major theme of this journal is to follow the path of scientific collaboration, spontaneity, and goodwill for the future, by providing up-to-date knowledge for the readers. The journal aims at covering different fields, as the name implies, ranging from research in basic and clinical sciences to core topics such as patient care, education, procuring and correct utilization of resources and bringing to limelight the cherished goals of the institute in providing a standard care for the physically disabled patients. This quarterly journal offers a venue for our researchers and scientists to vent their innovative and constructive research works. The scope of the journal is as far wide as the universe as being declared by the name of the journal, but our aim is to pursue our sacred goals in providing a panacea for the intractable ailments, which leave a psychological element in the daily life of such patients. This authoritative clinical and basic journal was founded by Professor Madjid Samii in 2012.