Implication of the LINGO2 gene in the predisposition to movement disorders

Abstract

Previous reports on the pathogenesis of age-related movement disorders, such as Parkinson’s disease (PD) and essential tremor (ET), have demonstrated the potential implications of LINGO1 (leucine-rich repeat and immunoglobulin domain-containing protein) gene. Although LINGO2 has a high degree of homology with LINGO1, but it is less characterized and the role of LINGO2 in the development of PD/ET remains unreported. Hence, this meta-analysis was conducted to evaluate the role of LINGO2 in PD/ET pathogenesis. A total of 4 studies, which complied with the Hardy–Weinberg equilibrium, were included in the meta-analysis. Analysis of the pooled odds ratio and confidence interval of the studies were performed for five genetic models, namely: allelic, dominant, recessive, homozygous, and heterozygous. No significant association was observed between the LINGO2 polymorphism and PD/ET, although subgroup analysis through conventional meta-analysis indicated that the recessive models of rs7033345 and rs10812774 are significantly associated with predisposition to ET in the Asian population. However, trial sequential analyses for both polymorphisms were unlikely to reveal any robust effect. Hence, studies with larger samples on this association are needed in the future to corroborate our results.