Histopathological changes in the kidney tissues of White Swiss Mice (Mus musculus L.) exposed to α-Cypermethrin

Abstract

α- Cypermethrin is a pyrethroid insecticide. Chronic exposure to α -cypermethrin for use in household pest control or through drinking water and fruits and vegetables contaminated with it. The kidneys are an essential organ in the human and animal body because they perform a number of major functions. One of the causes of nephrotoxicity is exposure to environmental pollutants, which often lead to direct injury to the kidney tissues, causing pathological changes. The current study was designed to investigate the deleterious effects of α- Cypermethrin when taken in two doses in the kidney tissues of Swiss laboratory mice. And the Humasan method was used to prepare the tissue sections of the kidney. Treated mice groups showed many Histopathological changes in kidney, among these in low dose in females the shrinkage of some tubular cells nuclei and necrosis of others with vacuolization in cytoplasm of cells in the glomerular shape, the emergence of a clumping of mesenchymal cells in many regions with increased tubular cells enlargement. The effects varied in the form of bleeding at one time, congestion and edema at other times and aggregation of fat cells of different sizes and inflammation and death of renal cells. In males the effects varied in the form of loss of the glomerulus, congestion and dilation of Bowman's space, glomerular necrosis or loss of glomerulus,Hemorrhage congestion, renal cell death and cells hyperplasia. In females and males at high doses, the effects in females were represented by swelling of tubular cells, loss of the glomerulus, death of tubular cells again and loss of the renal glomeruli while in males they were represented by hemorrhage and death of the renal epithelium, loss of the glomerulus and congestion of its tubules. The results of this study confirmed that α- Cypermethrin causes seriously deteriorate in Kidney tissues of Albino Swiss mice.