Anti-inflammatory properties of pigment epithelium-derived factor

IF 0.6 4区 医学 Q4 IMMUNOLOGY
Ting He, Wei Liu, Chuan-an Shen
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引用次数: 0

Abstract

Inflammation is part of the complex biological response to harmful stimuli, such as cell damage, pathogens, or irritants. An excessive inflammatory response can lead to a variety of diseases. Pigment epithelium-derived factor (PEDF) is an endogenous glycoprotein that belongs to the superfamily of serine protease inhibitors and has multiple biological activities. Accumulating evidence suggests that PEDF participates in various inflammatory-related diseases, such as diabetic retinopathy, atherosclerosis, nonalcoholic steatohepatitis, and retinal diseases. However, the mechanism is still incompletely understood. In this paper, we review the anti-inflammatory properties of PEDF and discuss the underlying mechanisms. PEDF can exert its anti-inflammatory effects by downregulating the expression of inflammatory factors, promoting the synthesis of anti-inflammatory factors, inhibiting the activation of proinflammatory pathways and activating anti-inflammatory pathways. Examining the function of PEDF in inflammation addresses the need for further investigation and subsequent target-specific strategies for inflammatory disorders.
色素上皮衍生因子的抗炎特性
炎症是对有害刺激(如细胞损伤、病原体或刺激物)的复杂生物反应的一部分。过度的炎症反应会导致多种疾病。色素上皮衍生因子(PEDF)是一种内源性糖蛋白,属于丝氨酸蛋白酶抑制剂超家族,具有多种生物活性。越来越多的证据表明,PEDF参与各种炎症相关疾病,如糖尿病视网膜病变、动脉粥样硬化、非酒精性脂肪性肝炎和视网膜疾病。然而,其机制仍未完全了解。本文就PEDF的抗炎特性进行综述,并讨论其抗炎机制。PEDF通过下调炎症因子的表达,促进抗炎因子的合成,抑制促炎通路的激活,激活抗炎通路来发挥抗炎作用。检查PEDF在炎症中的功能,需要进一步研究和随后针对炎症疾病的靶向性策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
0.90
自引率
0.00%
发文量
54
审稿时长
15 weeks
期刊介绍: European Journal of Inflammation is a multidisciplinary, peer-reviewed, open access journal covering a wide range of topics in inflammation, including immunology, pathology, pharmacology and related general experimental and clinical research.
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