The signature of intestinal dysbiosis in inflammatory rheumatic diseases

Q4 Medicine
A. Cardoneanu, R. P. Iași, A. Burlui, E. Rezus
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引用次数: 0

Abstract

The study of intestinal microbiota is an important and current subject. It is well known that the gut microbiota plays a decisive role in the development of intestinal function, contributes to the defense against different infections, gives tolerance to ingested foods, regulating and maintaining the function of the intestinal barrier. The gut microbiota is different from individual to individual, determining, through the molecular profile, an “individual profile”. Intestinal dysbiosis is associated with multiple diseases such as IBD, irritable bowel syndrome, nosocomial infections or rheumatic inflammatory disorders. By characterizing intestinal dysbiosis in patients, a link could be made between these bacteria and the pathogenic mechanisms of the diseases, assigning these structures key roles in the onset of systemic disorders. This allows a better understanding of the pathophysiological mechanisms of the diseases and allow having a targeted treatment aimed at improving dysbiosis and restoring the normal microbial gut profile.
炎症性风湿病肠道生态失调的特征
肠道菌群的研究是一项重要的前沿课题。众所周知,肠道微生物群在肠道功能的发育中起着决定性的作用,有助于防御不同的感染,对摄入的食物产生耐受性,调节和维持肠道屏障的功能。肠道微生物群因人而异,通过分子谱决定了“个体谱”。肠道生态失调与多种疾病有关,如IBD、肠易激综合征、医院感染或风湿性炎症性疾病。通过表征患者的肠道生态失调,可以在这些细菌和疾病的致病机制之间建立联系,赋予这些结构在全身性疾病发病中的关键作用。这可以更好地理解疾病的病理生理机制,并允许有针对性的治疗,旨在改善生态失调和恢复正常的肠道微生物特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
0.10
自引率
0.00%
发文量
22
审稿时长
4 weeks
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