A single application of cold atmospheric plasma (CAP) improves blood flow parameters in chronic wounds

IF 1.9 4区医学 Q3 HEMATOLOGY

Microcirculation Pub Date : 2022-02-26 DOI:10.1111/micc.12754

Sophie Schleusser, Lysann Schulz, Jungin Song, Henriette Deichmann, Anna-Catharina Griesmann, Felix H. Stang, Peter Mailaender, Robert Kraemer, Markus Kleemann, Tobias Kisch

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引用次数: 2

Abstract

Objective

To find out whether application of cold atmospheric plasma (CAP) affects microcirculation in chronic wounds.

Methods

We treated 20 patients with chronic wounds on the lower extremity with CAP. Blood flow parameters of wounds were assessed with combined Laser-Doppler-Flowmetry and spectrophotometry in tissue depth of 2 and 6–8 mm. Parameters were assessed under standardized conditions before and over the course of 30 min after application of CAP.

Results

Deep capillary blood flow increased significantly by up to 24.33% (percentage change) after treatment with CAP and remained significantly elevated until the end of measuring period at 30 min. Superficial oxygen tissue saturation was significantly elevated by 14.05% for the first 5 min after treatment. Postcapillary venous filling pressure was significantly elevated by 10.23% 19 min after CAP and stayed significantly elevated starting from minute 24 until the end of measuring.

Conclusion

Cold atmospheric plasma increases microcirculation parameters in chronic wounds significantly. As CAP is known for its benefits in wound healing, the effects observed may explain the improved healing of chronic wounds after its use. Whether CAP-application can increase blood flow in chronic wounds for longer periods of time or boosts blood flow when applied more than once should be subject to further research.

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低温大气等离子体(CAP)的单一应用改善了慢性伤口的血流参数

目的探讨低温常压等离子体(CAP)对慢性创面微循环的影响。方法对20例下肢慢性创面进行CAP治疗，采用激光-多普勒血流法和分光光度法对创面2、6 ~ 8 mm组织深度血流参数进行评价。在应用CAP前和30 min后的标准化条件下评估参数。结果CAP治疗后深层毛细血管血流量显著增加24.33%(百分比变化)，并在30 min测量期结束时保持显著升高治疗后5分钟。术后19 min，毛细血管后静脉充盈压力显著升高10.23%，且从24 min开始持续升高至测量结束。结论低温大气等离子体可显著提高慢性创伤微循环参数。由于CAP因其在伤口愈合中的益处而闻名，观察到的效果可能解释了使用后慢性伤口愈合的改善。cap的应用是否能长期增加慢性伤口的血流量，或者在多次应用时是否能促进血流量，还有待进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microcirculation 医学-外周血管病

CiteScore

5.00

自引率

4.20%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal features original contributions that are the result of investigations contributing significant new information relating to the vascular and lymphatic microcirculation addressed at the intact animal, organ, cellular, or molecular level. Papers describe applications of the methods of physiology, biophysics, bioengineering, genetics, cell biology, biochemistry, and molecular biology to problems in microcirculation. Microcirculation also publishes state-of-the-art reviews that address frontier areas or new advances in technology in the fields of microcirculatory disease and function. Specific areas of interest include: Angiogenesis, growth and remodeling; Transport and exchange of gasses and solutes; Rheology and biorheology; Endothelial cell biology and metabolism; Interactions between endothelium, smooth muscle, parenchymal cells, leukocytes and platelets; Regulation of vasomotor tone; and Microvascular structures, imaging and morphometry. Papers also describe innovations in experimental techniques and instrumentation for studying all aspects of microcirculatory structure and function.