A Certain Electrochemical Nanosensor Based on Functionalized Multi-Walled Carbon Nanotube for Determination of Cysteine in the Presence of Paracetamol

IF 1.4 Q4 NANOSCIENCE & NANOTECHNOLOGY

Journal of Nanostructures Pub Date : 2020-04-01 DOI:10.22052/JNS.2020.02.006

M. Mazloum‐Ardakani, Z. Alizadeh

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引用次数: 7

Abstract

The modified glassy carbon electrode (GCE) was prepared with 6-amino-4-(3,4-dihydroxyphenyl)-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile (pyrazole derivative (AMPC)) and functionalized multi-walled carbon nanotubes. In this research, electrocatalytic activity of nanocomposite (AMPC/MWCNTs) has been studied by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and chronoamperometry (CHA) methods. The electrocatalytic properties of the AMPC/MWCNTs nanocomposite for cysteine oxidation was considerably enhanced as compared to only AMPC. The kinetic parameters including the electron transfer coefficient (α) and the heterogeneous constant rate (k’) for oxidation of cysteine was studied by CV method. The diffusion coefficient of cysteine was calculated with aid of chronoamperometry (D=9.51×10-6 cm2/s). The AMPC/MWCNTs modified electrode shows a linear response to cysteine in the range of 0.7 nM to 200.0 µM with detection limit of 0.16 nM. Also, differential pulse voltammetry was applied for the simultaneous determination of cysteine (CYS) and paracetamol (or acetaminophen, AC). Finally, the modified electrode was used for the detection of CYS and AC in human serums (real samples). The sensor produced good sensitivity, selectivity, reproducibility and stability features.

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基于功能化多壁碳纳米管的电化学纳米传感器测定对乙酰氨基酚中半胱氨酸的研究

用6-氨基-4-（3，4-二羟基苯基）-3-甲基-1，4-二氢吡并[2，3-c]吡唑-5-腈（吡唑衍生物（AMPC））和功能化的多壁碳纳米管制备了改性玻碳电极（GCE）。本研究采用循环伏安法（CV）、微分脉冲伏安法（DPV）和计时电流法（CHA）研究了纳米复合材料（AMPC/MWCNTs）的电催化活性。与仅AMPC相比，AMPC/MWCNTs纳米复合材料对半胱氨酸氧化的电催化性能显著增强。用CV法研究了半胱氨酸氧化的动力学参数，包括电子转移系数（α）和非均相恒定速率（k’）。用计时电流法计算半胱氨酸的扩散系数（D=9.51×10-6cm2/s）。AMPC/MWCNTs修饰电极对半胱氨酸的线性响应范围为0.7 nM至200.0µM，检测限为0.16 nM。同时，应用微分脉冲伏安法同时测定半胱氨酸（CYS）和对乙酰氨基酚（或对乙酰氨基苯酚，AC）。最后，将修饰电极用于人体血清（真实样品）中CYS和AC的检测。该传感器具有良好的灵敏度、选择性、再现性和稳定性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nanostructures NANOSCIENCE & NANOTECHNOLOGY-

CiteScore

2.60

自引率

0.00%

发文量

审稿时长

7 weeks

期刊介绍： Journal of Nanostructures is a medium for global academics to exchange and disseminate their knowledge as well as the latest discoveries and advances in the science and engineering of nanostructured materials. Topics covered in the journal include, but are not limited to the following: Nanosystems for solar cell, energy, catalytic and environmental applications Quantum dots, nanocrystalline materials, nanoparticles, nanocomposites Characterization of nanostructures and size dependent properties Fullerenes, carbon nanotubes and graphene Self-assembly and molecular organization Super hydrophobic surface and material Synthesis of nanostructured materials Nanobiotechnology and nanomedicine Functionalization of nanostructures Nanomagnetics Nanosensors.