One pot multicomponent synthesis of highly functionalized tri-substituted imidazole derivatives using TiO2-rGO nanocomposite as a recyclable catalyst

IF 2.218 Q2 Chemistry

Chemical Data Collections Pub Date : 2023-10-01 DOI:10.1016/j.cdc.2023.101075

Vivek S. Ingale , Kiran N. Patil , Pankaj S. Dafale , Deepak A. Kumbhar , Pravin R. Kharade , Uttam B. Chougale

引用次数: 0

Abstract

In this study, we present a simple , environmentally benign and highly efficient protocol for the synthesis of highly functionalized tri-substituted imidazole derivatives. The synthesis involves the reaction of one molecule of benzil, one molecule of various substituted aromatic aldehydes and three molecules of ammonium acetate, taking place at 110 ^oC under solvent free condition. The reaction is facilitated by TiO₂-rGO nanocomposite as a dynamic nano-catalyst. The appealing characteristics of this protocol are easy workup procedure, equable reaction conditions, solvent free, reusability of the catalyst and developed synthesis which avoid purification processes like chromatography.

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以TiO2-rGO纳米复合材料为可回收催化剂，一锅多组分合成高功能化三取代咪唑衍生物

在这项研究中，我们提出了一种简单、环保、高效的方案来合成高功能化的三取代咪唑衍生物。在无溶剂条件下，在110℃的温度下，由1分子苄基、1分子各种取代芳醛和3分子乙酸铵进行合成。TiO2-rGO纳米复合材料作为动态纳米催化剂促进了反应的进行。该方案的吸引人的特点是简单的处理程序，均匀的反应条件，无溶剂，催化剂的可重复使用和先进的合成，避免了纯化过程，如色谱。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical Data Collections Chemistry-Chemistry (all)

CiteScore

6.10

自引率

0.00%

发文量

169

审稿时长

24 days

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