Prediction of Coffee Effects in Rats with Healthy and NAFLD Conditions Based on Protein-Protein Interaction Network Analysis

IF 1.1 Q4 PHARMACOLOGY & PHARMACY

Research Journal of Pharmacognosy Pub Date : 2019-10-01 DOI:10.22127/RJP.2019.93500

M. Rezaei-Tavirani, M. Tavirani, M. Azodi, Z. Akbari, H. Hajimehdipoor

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引用次数: 6

Abstract

Background and objectives: Non-alcoholic fatty liver disease (NAFLD) is a common liver condition. On the other hand, coffee consumption has shown promising for gastrointestinal diseases. Detection of the most valuable biomarkers of decaffeinated coffee treatment in healthy and non-alcoholic fatty liver disease conditions was the aim of the present study. Methods: A previous proteomics study about effect of decaffeinated coffee (1.5 mL daily drinking coffee for two months) on protein expression change of rat liver was selected for protein-protein interaction (PPI) network analysis via Cytoscape v.3.7.1 and the related applications. The most central proteins with regards to a high degree and betweenness centralities in the coffee treatment condition of healthy and NAFLD were then analyzed by ClueGO for biological process (BP) derivation. Results: HSPA5, HSPA4, HSPA9, HSPA7, PARK7, HSP90AA1, P4HB, PRDX1, and PDIA3 were introduced as central proteins, which are involved in folding and antioxidant activities. Conclusion: There is a complicated combination of the components in coffee; some elements are involved in liver protection against NAFLD and the others are in contrast.

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基于蛋白-蛋白相互作用网络分析预测咖啡对健康大鼠和NAFLD的影响

背景与目的：非酒精性脂肪肝（NAFLD）是一种常见的肝脏疾病。另一方面，饮用咖啡对胃肠道疾病有很大的治疗前景。检测无咖啡因咖啡治疗健康和非酒精性脂肪肝最有价值的生物标志物是本研究的目的。方法：通过Cytoscape v.3.7.1及其相关应用，选择先前关于无咖啡因咖啡（每天喝1.5 mL咖啡，持续两个月）对大鼠肝脏蛋白质表达变化影响的蛋白质组学研究进行蛋白质-蛋白质相互作用（PPI）网络分析。然后，通过ClueGO分析健康人和NAFLD的咖啡处理条件下与高度和中间性集中有关的大多数中心蛋白的生物过程（BP）推导。结果：HSPA5、HSPA4、HSPA9、HSPA7、PARK7、HSP90AA1、P4HB、PRDX1和PDIA3作为中心蛋白被引入，参与折叠和抗氧化活性。结论：咖啡中存在复杂的成分组合；一些元素参与对NAFLD的肝脏保护，而另一些则相反。

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