Toxicity Assessment of Biologically Degraded Product of Textile Dye Acid Red G

Q3 Pharmacology, Toxicology and Pharmaceutics
P. Faldu, V. Kothari, C. Kothari, Jalpa K. Rank, A. Hinsu, R. Kothari
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引用次数: 0

Abstract

Azo dyes are of environmental concern due to their recalcitrant nature. Several azo dyes and their decolorized and degraded products exert toxic and mutagenic effects on the flora and fauna. The toxic properties of these azo dyes are due to nature and position of the substitution with respect to the aromatic rings and amino nitrogen atoms. Several studies have thus far been emphasized on biodegradation of azo dye pollutants, though role of their biodegraded product is rarely studied. Given a lack of this understanding, we have analyzed the effects of degraded products of a di-azo textile dye Acid Red G by newly isolated bacterial species, Pseudomonas aeruginosa PFK10 and Brevibacillus choshinensis PFK11. The genotoxicity and cytotoxicity of Acid Red G and their degraded products were tested on HeLa cell line and Human lymphocyte cell, respectively. The data of MTT assay has been shown that activity of degraded products of the Acid Red G were comparable to their parent dye. But chromosome aberration assay and sister chromatid exchange assay did not show any significant changes in chromosomes as compared to positive control mitomicine.
纺织染料酸性红G生物降解产物的毒性评价
偶氮染料由于其难降解性而引起环境问题。几种偶氮染料及其脱色降解产物对动植物具有毒性和诱变作用。这些偶氮染料的毒性是由于取代的性质和位置相对于芳环和氨基氮原子。迄今为止,一些研究强调了偶氮染料污染物的生物降解,但很少研究其生物降解产物的作用。鉴于缺乏这一认识,我们分析了新分离的细菌铜绿假单胞菌PFK10和中国短杆菌PFK11对二偶氮纺织染料酸性红G降解产物的影响。分别在HeLa细胞系和人淋巴细胞上检测了酸性红G及其降解产物的遗传毒性和细胞毒性。MTT分析数据表明,酸性红G降解产物的活性与其母体染料相当。但染色体畸变试验和姐妹染色单体交换试验与阳性对照有丝分裂素相比,染色体没有任何显著变化。
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来源期刊
Defence Life Science Journal
Defence Life Science Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
0.80
自引率
0.00%
发文量
26
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