Comparison of Postoperative Analgesic Effect of Magnesium Sulfate and Gabapentin in Patients Undergoing Laparoscopic Cholecystectomy

Q4 Medicine
Bita Barghi, Elahe Shakibi, Somayae Abdollahi Sabet, V. Rashtchi
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引用次数: 1

Abstract

Background and Objective: Considering the importance of pain management using effective medicines, the present study aimed to compare the analgesic effect of magnesium sulfate and gabapentin on postoperative pain in patients undergoing laparoscopic cholecystectomy. Materials and Methods: The present randomized clinical trial study was conducted on patients undergoing laparoscopic cholecystectomy in the operating room of Ayatollah Mousavi Hospital in Zanjan in 2019. The patients were assigned to three groups of 30 using the block randomization method. One group received 50 mg/kg of magnesium sulfate in 100 ml of normal saline within 1 h during the operation, the second group received 600 mg of gabapentin capsule 1 h before the operation, and the third group did not receive any additional medicines. The overall opioid dose, the time of the first analgesic request, and the Visual Analogue Scale (VAS ), 6, 12, 18, and 24 h postoperatively were compared in the three groups using repeated measures of ANOVA. Results: Based on the results, there was not a significant difference among the three groups in terms of gender and age (P>0.05). Moreover, the three groups t significantly differ in pain and drug dose received (P<0.001). The results of the Tukey post hoc test demonstrated that the pain and drug dose received in the control group was significantly higher than those in both intervention groups (P<0.001). Nonetheless, this difference between the two groups of magnesium sulfate and gabapentin was not statistically significant (P>0.05). Conclusion: As evidenced by the obtained results, in patients undergoing laparoscopic cholecystectomy, gabapentin and magnesium sulfate significantly reduced pain intensity and the need to use drugs; however, there was no significant difference between the two drugs.
硫酸镁与加巴喷丁对腹腔镜胆囊切除术后镇痛效果的比较
背景与目的:考虑到使用有效药物进行疼痛管理的重要性,本研究旨在比较硫酸镁和加巴喷丁对腹腔镜胆囊切除术后疼痛的镇痛作用。材料和方法:本随机临床试验研究于2019年在赞詹Ayatollah Mousavi医院手术室对接受腹腔镜胆囊切除术的患者进行。采用分组随机化方法将患者分为三组,每组30人。一组在手术期间1小时内接受50mg/kg硫酸镁在100ml生理盐水中的溶液,第二组在手术前1小时接受600mg加巴喷丁胶囊,第三组不接受任何额外的药物。使用ANOVA重复测量,比较三组患者术后6、12、18和24小时的阿片类药物总剂量、首次镇痛请求时间和视觉模拟量表(VAS)。结果:三组患者性别、年龄差异无统计学意义(P>0.05),疼痛和用药剂量差异有统计学意义(P0.05),加巴喷丁和硫酸镁显著降低了疼痛强度和用药需求;然而,两种药物之间没有显著差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
0.30
自引率
0.00%
发文量
16
审稿时长
8 weeks
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