The pathogenic roles of lncRNAs in glioma

Abstract

Brain cancers or intracranial cancers are among the deadliest cancers in the world. The presence of tumorigenic cancer cells in the brain and induction of poor prognosis may impact the survival/death balance. Glioma is a type of brain tumor that begins in the glial tissue. Recently, it has been reported that long non-coding RNAs (lncRNAs) with at least 200 nucleotides in length by targeting DNAs, RNAs, and proteins play essential roles in several biological processes, including growth, differentiation, and development. Recently, lncRNAs was reported to contribute to the tumorigenesis of glioma by targeting miRNAs, other ncRNAs, and mRNAs. In this review, we focused on the functional roles of lnRNAs in glioma.