The Role of TGF-β, Activin and Follistatin in Inflammatory Bowel Disease

IF 0.9 Q4 GASTROENTEROLOGY & HEPATOLOGY
Nasim Hatamzade Esfahani, A. Day
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引用次数: 1

Abstract

Inflammatory bowel disease (IBD) is an immune-mediated inflammatory condition predominantly affecting the gastrointestinal (GI) tract. An increasing prevalence of IBD has been observed globally. The pathogenesis of IBD includes a complex interplay between the intestinal microbiome, diet, genetic factors and immune responses. The consequent imbalance of inflammatory mediators ultimately leads to intestinal mucosal damage and defective repair. Growth factors, given their specific roles in maintaining the homeostasis and integrity of the intestinal epithelium, are of particular interest in the setting of IBD. Furthermore, direct targeting of growth factor signalling pathways involved in the regeneration of the damaged epithelium and the regulation of inflammation could be considered as therapeutic options for individuals with IBD. Several members of the transforming growth factor (TGF)-β superfamily, particularly TGF-β, activin and follistatin, are key candidates as they exhibit various roles in inflammatory processes and contribute to maintenance and homeostasis in the GI tract. This article aimed firstly to review the events involved in the pathogenesis of IBD with particular emphasis on TGF-β, activin and follistatin and secondly to outline the potential role of therapeutic manipulation of these pathways.
TGF-β、激活素和卵泡抑素在炎症性肠病中的作用
炎症性肠病(IBD)是一种主要影响胃肠道的免疫介导的炎症性疾病。IBD的患病率在全球范围内呈上升趋势。IBD的发病机制包括肠道微生物组、饮食、遗传因素和免疫反应之间的复杂相互作用。随之而来的炎症介质失衡最终导致肠粘膜损伤和修复缺陷。鉴于生长因子在维持肠上皮稳态和完整性方面的特殊作用,它们对IBD的发生特别感兴趣。此外,直接靶向参与受损上皮再生和炎症调节的生长因子信号通路可以被视为IBD患者的治疗选择。转化生长因子(TGF)-β超家族的几个成员,特别是TGF-β、激活素和卵泡抑素,是关键的候选者,因为它们在炎症过程中表现出各种作用,并有助于胃肠道的维持和稳态。本文旨在首先综述IBD发病机制中涉及的事件,特别是TGF-β、激活素和卵泡抑素,其次概述这些途径的潜在治疗作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.50
自引率
0.00%
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0
审稿时长
10 weeks
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