In-Vitro Fertilization Outcome in Patients with Polycystic Ovary Syndrome: Role of Age and Maternal Body Weight

Abstract

Objective: to evaluate the impact of pre-gestational maternal age and body weight on the outcome of IVF in women with PCOS. Design: a retrospective study on women with PCOS undergoing IVF. Methods: Medical records of 200 known cases of polycystic ovary syndrome women treated in a third level referral center by the same therapeutic protocol were evaluated retrospectively. Demographic data, maternal body mass index, hormonal profile (LH, FSH, estradiol, anti-mullerian), IVF cycle parameters and outcome were documented. Patients were classified to three groups based on their body mass index (Normal: 18.5-24.9, overweight: 25-30, obese≥30). IVF cycle parameters and outcome were compared in these 3 groups. Effect of age was also evaluated by comparing the results in patients aged <35 and ≥35. Results: Mean age of patients was 32.5 (±5.2). 72 patients had normal BMI, 85 patients were overweighed and 43 cases were obese. Baseline hormonal profile was similar in 3 groups. Total dose of administered FSH were similar in 3 groups. Number of retrieved oocytes was statistically significant higher in patients with BMI>30 but the number of mature oocytes and number of embryos were statistically lower in this group. Size of follicles showed no statistically significant difference in 3 groups. Clinical pregnancy rate was statistically significant lower in patients with BMI>30 kg/m2 and age>35 years old. Conclusions: BMI>30 and age >35 years old has a statistically significant negative impact on IVF success rate.