Comparison of the effects of potassium citrate and hydrochlorothiazide on the ureteral stent encrustation in patients with long stent survival; a single-blinded clinical trial

IF 0.2 Q4 UROLOGY & NEPHROLOGY

Journal of Renal Injury Prevention Pub Date : 2022-01-08 DOI:10.34172/jrip.2022.25804

S. Farshid, M. Reza Roshandel, A. Tehranchi, H. Ranjbar, R. Valizadeh

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引用次数: 0

Abstract

Introduction: The probability of encrustation after embedding ureteral stent is 9.6% in six weeks, 47.5% in 6 to 12 weeks and 76.3% in more than 12 weeks. Objectives: This study was designed to evaluate the effect of potassium citrate and hydrochlorothiazide on ureteral stent encrustation as a single-blinded clinical trial. Patients and Methods: After embedding ureteral stent in 130 patients, the individuals were randomly divided into two groups using random allocation software. Convenience sampling method was used in this study. One group was given hydrochlorothiazide and potassium citrate, and the other group did not receive any medication. All stents were the same brand and the maximum time of stents being in situ was six weeks. Four to six weeks after stent implantation, patients were referred for stent removal. Then, ureteral stent encrustation was recorded in the two groups according to the visual appearance and the difficulty in stent removing due to stent encrustation. Results: The mean age of the patients was 42.62±14.86 years. Regarding gender, 78 patients (67.8%) were male and 37 patients (32.2%) were female. In this study, 15 patients (13%) had ureteral stent encrustation, of which 13 patients (20%) were in the group without medication and two patients (4%) were in the group who received hydrochlorothiazide and potassium citrate (P = 0.012). Conclusion: The rate of ureteral stent encrustation in the patients who received hydrochlorothiazide and potassium citrate was significantly lower than the patients in the control group. This can be justified by the diuretic properties of hydrochlorothiazide and the reduction of urinary calcium levels. Additionally, high urinary citrate level and induction of urinary alkalization after the administration of potassium citrate. Are the ameliorating factors. Trial Registration: Registration of trial protocol has been approved by Iranian Registry of Clinical Trials (identifier: IRCT20180625040232N3, https://en.irct.ir/trial/46227, ethical code# IR.UMSU. REC.1396.130).

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柠檬酸钾和氢氯噻嗪对支架长期存活患者输尿管支架结垢的影响比较；单盲临床试验

引言：植入输尿管支架后，6周内发生结垢的概率为9.6%，6至12周为47.5%，12周以上为76.3%。目的：本研究旨在评估柠檬酸钾和氢氯噻嗪对输尿管支架结垢的影响，作为一项单盲临床试验。患者和方法：130例患者植入输尿管支架后，使用随机分配软件将患者随机分为两组。本研究采用方便抽样法。一组给予氢氯噻嗪和柠檬酸钾，另一组不接受任何药物治疗。所有支架均为同一品牌，支架原位放置的最长时间为六周。支架植入后4至6周，患者被转诊进行支架移除。然后，根据视觉外观和支架结垢导致的支架取出困难程度，记录两组输尿管支架结垢情况。结果：患者平均年龄42.62±14.86岁。关于性别，78名患者（67.8%）为男性，37名患者（32.2%）为女性。本研究15例（13%）发生输尿管支架结垢，其中13例（20%）为未用药组，2例（4%）为氢氯噻嗪加柠檬酸钾组（P=0.012）。这可以通过氢氯噻嗪的利尿特性和降低尿钙水平来证明。此外，服用柠檬酸钾后，尿中柠檬酸盐水平高，并诱发尿碱化。是改善因素。试验注册：试验方案的注册已获得伊朗临床试验注册处的批准（标识符：IRCT20180625040232N3，https://en.irct.ir/trial/46227，伦理规范#IR.UMSU.REC.1396.130）。

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来源期刊

Journal of Renal Injury Prevention UROLOGY & NEPHROLOGY-

CiteScore

1.60

自引率

0.00%

发文量

期刊介绍： The Journal of Renal Injury Prevention (JRIP) is a quarterly peer-reviewed international journal devoted to the promotion of early diagnosis and prevention of renal diseases. It publishes in March, June, September and December of each year. It has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views and renal biopsy teaching point. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of renal failure and modalities in the treatment of diabetic nephropathy. A further aim of this journal is to emphasize and strengthen the link between renal pathologists/nephropathologists and nephrologists. In addition, JRIP welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical nephrology. Futuristic conceptual hypothesis that integrate various fields of acute kidney injury and renal tubular cell protection are encouraged to be submitted.