{"title":"The gut microbiome's potential to influence arsenic exposure","authors":"Qian Wang, Nicholas V. Pinkham, Seth T. Walk","doi":"10.1016/j.cotox.2023.100431","DOIUrl":null,"url":null,"abstract":"<div><p><span>More than 200 million people around the world are exposed to unsafe levels of the environmental toxicant, arsenic. Both acute and chronic exposures, primarily through contaminated drinking water, are significant public health concerns. Human genetics<span> does not fully explain observed arsenic-related diseases (arsenicosis), suggesting that other factors such as the microbiome play important roles in determining risk following exposure. Microorganisms have evolved diverse pathways for mitigating the toxic effects of arsenic, which may theoretically increase or decrease human </span></span>arsenicosis<span><span> by altering toxicity. Here, we review the current state-of-the-art regarding the genetic<span> potential of microorganisms to influence arsenic toxicity, drawing particular attention to microbial arsenic </span></span>biotransformation.</span></p></div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"36 ","pages":"Article 100431"},"PeriodicalIF":6.1000,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468202023000463","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"TOXICOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
More than 200 million people around the world are exposed to unsafe levels of the environmental toxicant, arsenic. Both acute and chronic exposures, primarily through contaminated drinking water, are significant public health concerns. Human genetics does not fully explain observed arsenic-related diseases (arsenicosis), suggesting that other factors such as the microbiome play important roles in determining risk following exposure. Microorganisms have evolved diverse pathways for mitigating the toxic effects of arsenic, which may theoretically increase or decrease human arsenicosis by altering toxicity. Here, we review the current state-of-the-art regarding the genetic potential of microorganisms to influence arsenic toxicity, drawing particular attention to microbial arsenic biotransformation.
期刊介绍：
The aims and scope of Current Opinion in Toxicology is to systematically provide the reader with timely and provocative views and opinions of the highest qualified and recognized experts on current advances in selected topics within the field of toxicology. The goal is that Current Opinion in Toxicology will be an invaluable source of information and perspective for researchers, teachers, managers and administrators, policy makers and students. Division of the subject into sections: For this purpose, the scope of Toxicology is divided into six selected high impact themed sections, each of which is reviewed once a year: Mechanistic Toxicology, Metabolic Toxicology, Risk assessment in Toxicology, Genomic Toxicology, Systems Toxicology, Translational Toxicology.
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