The Antidepressant Effects of Domestic Natural Mixed Fragrance Ingredients in Animal Models

IF 2.6 4区心理学 Q2 BEHAVIORAL SCIENCES

Stress-The International Journal on the Biology of Stress Pub Date : 2023-06-30 DOI:10.17547/kjsr.2023.31.2.59

S. Jung

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引用次数: 0

Abstract

Background: This study used inhalation toxicity experiments, open field experiments, and tail suspension tests to investigate the antidepressant effect of a combination of nine types of refined oils extracted from domestic native plants.Methods: Non-irritability was confirmed through an inhalation toxicity test, locomotor activity was measured using an open field test, and the antidepressant effect was assessed by measuring immobility time during a tail suspension test.Results: The inhalation toxicity test confirmed that both samples were non-stimulated with a negative stimulation index of 0.0. In the tail suspension experiment, the floating time was significantly shorter than the depression model, with an average of 142.33±18.31 seconds compared to the control group at 0.5% concentration (F=10.582, p＜.001).Conclusions: This study’s results suggest that combining refined oils extracted from domestic native plants could be used to develop prototypes that effectively alleviate depression. Future studies should include usability evaluation and human application tests to further investigate these potential benefits.

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国产天然混合香精成分对动物模型的抗抑郁作用

背景:本研究采用吸入毒性实验、露天实验和悬尾实验等方法，研究了9种国产本土植物提取的成品油组合抗抑郁作用。方法:采用吸入毒性试验验证小鼠无激励性，采用开放场试验测定小鼠的运动活性，采用悬尾试验测定小鼠的静止时间来评估小鼠的抗抑郁作用。结果:吸入毒性试验证实两种样品均为非刺激，负刺激指数为0.0。尾悬实验中，悬浮时间明显短于凹陷模型，0.5%浓度下，悬浮时间平均为142.33±18.31秒(F=10.582, p<.001)。结论:本研究结果提示，结合国内本土植物提取的成品油可用于开发有效缓解抑郁症的原型。未来的研究应该包括可用性评估和人类应用程序测试，以进一步调查这些潜在的好处。

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来源期刊

Stress-The International Journal on the Biology of Stress 医学-行为科学

CiteScore

5.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal Stress aims to provide scientists involved in stress research with the possibility of reading a more integrated view of the field. Peer reviewed papers, invited reviews and short communications will deal with interdisciplinary aspects of stress in terms of: the mechanisms of stressful stimulation, including within and between individuals; the physiological and behavioural responses to stress, and their regulation, in both the short and long term; adaptive mechanisms, coping strategies and the pathological consequences of stress. Stress will publish the latest developments in physiology, neurobiology, molecular biology, genetics research, immunology, and behavioural studies as they impact on the understanding of stress and its adverse consequences and their amelioration. Specific approaches may include transgenic/knockout animals, developmental/programming studies, electrophysiology, histochemistry, neurochemistry, neuropharmacology, neuroanatomy, neuroimaging, endocrinology, autonomic physiology, immunology, chronic pain, ethological and other behavioural studies and clinical measures.