Polymer-based porous microcarriers as cell delivery systems for applications in bone and cartilage tissue engineering

IF 16.8 1区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

International Materials Reviews Pub Date : 2020-02-10 DOI:10.1080/09506608.2020.1724705

Zhihua Zhou, Wei Wu, Jianjun Fang, Jingbo Yin

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引用次数: 43

Abstract

ABSTRACT For tissue regeneration or repair, a suitable temporary scaffold needs to be constructed for delivering regenerative cells to damaged or diseased tissue. Scaffold types are currently categorised into 3D monolithic scaffolds, hydrogels, and microcarriers. Among these scaffolds, microcarrier systems offer an attractive method for cell amplification and enhancement of phenotype expression, and they have emerged as powerful injectable carriers to repair and reconstruct irregular defects in tissues and organs. In this article, several important issues related to polymeric porous microcarriers for tissue engineering are reviewed. The properties of porous microcarriers, including surface chemistry, pore structure, typical particle size, and specific density, and the corresponding effects on cell cultures are discussed. The fabrication techniques and biomaterials investigated for porous microcarriers are summarised, and their advantages and disadvantages are outlined. Recent advancements in the application of porous microcarriers, including bone and cartilage tissue engineering, are also presented.

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聚合物基多孔微载体作为细胞递送系统在骨和软骨组织工程中的应用

摘要对于组织再生或修复，需要构建合适的临时支架，将再生细胞输送到受损或患病组织。支架类型目前分为3D单片支架、水凝胶和微载体。在这些支架中，微载体系统为细胞扩增和增强表型表达提供了一种有吸引力的方法，它们已成为修复和重建组织和器官中不规则缺陷的强大注射载体。本文综述了用于组织工程的聚合物多孔微载体的几个重要问题。讨论了多孔微载体的性质，包括表面化学、孔结构、典型粒径和比密度，以及对细胞培养的相应影响。综述了多孔微载体的制备技术和生物材料，并概述了它们的优缺点。还介绍了多孔微载体应用的最新进展，包括骨和软骨组织工程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Materials Reviews 工程技术-材料科学：综合

CiteScore

28.50

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： International Materials Reviews (IMR) is a comprehensive publication that provides in-depth coverage of the current state and advancements in various materials technologies. With contributions from internationally respected experts, IMR offers a thorough analysis of the subject matter. It undergoes rigorous evaluation by committees in the United States and United Kingdom for ensuring the highest quality of content. Published by Sage on behalf of ASM International and the Institute of Materials, Minerals and Mining (UK), IMR is a valuable resource for professionals in the field. It is available online through Sage's platform, facilitating convenient access to its wealth of information. Jointly produced by ASM International and the Institute of Materials, Minerals and Mining (UK), IMR focuses on technologies that impact industries dealing with metals, structural ceramics, composite materials, and electronic materials. Its coverage spans from practical applications to theoretical and practical aspects of material extraction, production, fabrication, properties, and behavior.