Advance in human papillomavirus major capsid protein L1-based vaccines

Q4 Immunology and Microbiology

中华微生物学和免疫学杂志 Pub Date : 2019-10-31 DOI:10.3760/CMA.J.ISSN.0254-5101.2019.010.011

Chunting Hua, Siyuan Sun, Hao Cheng, Rui Han

引用次数: 2

Abstract

L1 is the major capsid protein of human papillomavirus (HPV) encoded by late gene 1. Based on the fact that L1 can self-assemble into virus like particle (VLP) with good immunogenicity, it has aroused wide concern in studying the pathogenesis of and vaccines against HPV. Nevertheless, there are a few limitations of present L1-based HPV vaccines. For instance, low expression of the protein and the complexity of purification result in the relatively low yield of vaccines. Type-specific antibody induced by L1 also results in the unsatisfactory cross-protection rate. Furthermore, there is no reported therapeutic effect against HPV-related diseases because of its undefined role in virus eliminating. This review focused on the structure, immunogenicity and role in immune response of L1 and the development of and latest progress in HPV vaccines. Key words: Human papillomavirus; Major capsid protein L1; Virus like particle; HPV vaccine

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人乳头瘤病毒主要衣壳蛋白L1疫苗的研究进展

L1是由晚期基因1编码的人乳头瘤病毒（HPV）的主要衣壳蛋白。基于L1可以自组装成具有良好免疫原性的病毒样颗粒（VLP）这一事实，它在研究HPV的发病机制和疫苗方面引起了广泛关注。然而，目前基于L1的HPV疫苗存在一些局限性。例如，蛋白质的低表达和纯化的复杂性导致疫苗的产量相对较低。L1诱导的类型特异性抗体也导致不令人满意的交叉保护率。此外，由于其在消除病毒方面的作用尚不明确，目前还没有报道对HPV相关疾病的治疗效果。本文综述了L1的结构、免疫原性和在免疫应答中的作用，以及HPV疫苗的开发和最新进展。关键词：人乳头瘤病毒；主要衣壳蛋白L1；病毒样颗粒；HPV疫苗

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中华微生物学和免疫学杂志 Immunology and Microbiology-Virology

CiteScore

0.50

自引率

0.00%

发文量

6906

期刊介绍： Chinese Journal of Microbiology and Immunology established in 1981. It is one of the series of journal sponsored by Chinese Medical Association. The aim of this journal is to spread and exchange the scientific achievements and practical experience in order to promote the development of medical microbiology and immunology. Its main contents comprise academic thesis, brief reports, reviews, summaries, news of meetings, book reviews and trends of home and abroad in this field. The distinguishing feature of the journal is to give the priority to the reports on the research of basic theory, and take account of the reports on clinical and practical skills.