Reviewing Treatments for Cocaine Consume Problems: The Gabapentinoid Alternative

IF 1.4 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Gabriel C Quintero Garzola
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引用次数: 0

Abstract

Background: Cocaine use disorder is a worldwide problem. Presently, however, no adequate treatments exist. Gabapentin has been explored recently as an alternative for treating different substance use disorders, including cocaine. Methods: The aim of the present paper is to assess the effectiveness of gabapentin for treating cocaine use disorders. For this purpose, a systematic review of the literature was performed using the publication database, PubMed, with search limits from January 1, 1983 to February 28, 2018. The search terms used were combined as follows: “gabapentin” AND “cocaine”. Initially, 41 articles were identified, with additional 23 articles identified through reference exploration or web search. These 23 complementary articles relate mainly to the general description of gabapentin and discussion. After the analysis of the titles and abstracts, 18 references were removed, resulting in 46 articles for further analysis. Results and Discussion: Gabapentin is inadequate for treating cocaine dependence and relapse, and alleviating the subjective effects of cocaine. More research is necessary for exploring gabapentin alleviation of cocaine intoxication, and further investigation is required for confirming the gabapentin’s utility for treating cocaine addiction.
回顾可卡因消费问题的治疗:加巴喷丁类药物的替代品
背景:可卡因使用障碍是一个全球性的问题。然而,目前还没有足够的治疗方法。加巴喷丁最近被探索作为治疗包括可卡因在内的不同物质使用障碍的替代品。方法:评价加巴喷丁治疗可卡因使用障碍的疗效。为此,使用出版物数据库PubMed对1983年1月1日至2018年2月28日的文献进行了系统综述,检索范围为。使用的搜索词组合如下:“加巴喷丁”和“可卡因”。最初,共确定了41篇文章,另有23篇文章是通过参考资料探索或网络搜索确定的。这23篇补充文章主要涉及加巴喷丁的一般描述和讨论。在对标题和摘要进行分析后,删除了18篇参考文献,产生了46篇文章供进一步分析。结果与讨论:加巴喷丁不足以治疗可卡因依赖和复发,也不足以减轻可卡因的主观影响。需要更多的研究来探索加巴喷丁对可卡因中毒的缓解作用,还需要进一步的研究来证实加巴喷汀对治疗可卡因成瘾的效用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Open Access Journal of Clinical Trials
Open Access Journal of Clinical Trials MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
3.90
自引率
0.00%
发文量
2
审稿时长
16 weeks
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