Preparation of thermal-responsive Pickering emulsion by ATRP modified lignin microspheres

IF 1.7 4区农林科学 Q2 MATERIALS SCIENCE, PAPER & WOOD

Journal of Wood Chemistry and Technology Pub Date : 2022-09-20 DOI:10.1080/02773813.2022.2123518

Rui Wen, Shiyu Fu

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Abstract

Abstract Soda lignin or lignosulfonate from paper mills are often directly applied as surfactant for cement dispersion due to the presence of hydrophilic and hydrophobic groups in lignin. They are also applied to Pickering emulsion, but the efficiency is not so good. In this work, we modified lignin by grafting poly(ethylene glycol) methyl ether methacrylate (PEGME), and then the modified-lignin self-assembled into microspheres that was applied to a lignin-based Pickering emulsion with temperature responsiveness. The particle size of modified-lignin microspheres changed with temperature due to the thermoresponsiveness of the grafted polymer, which also subsequently affect the radius of emulsion droplets. The lower critical solution temperature (LCST) of the modified lignin is 50 °C. When temperature changed from 25 °C to 70 °C, the average particle size of lignin microspheres decreased from 159 nm to 141 nm. Further rising temperature caused the lignin microspheres to agglomerate and to break the Pickering emulsion. The prepared Pickering emulsion is good for drug agent loading and stably-releasing. It is found that the cumulative drug release changed from 43.77% to over 80% after 14 hours at 25 °C and over 50 °C. The lignin-based Pickering emulsion have good thermal cycling stability and ionic resistance, which may offer a potential for the drug release.

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ATRP修饰木质素微球制备热响应皮克林乳液

摘要造纸厂的碱木质素或木质素磺酸盐由于木质素中存在亲水性和疏水性基团，通常直接用作水泥分散的表面活性剂。它们也应用于皮克林乳液，但效果不太好。在这项工作中，我们通过接枝聚乙二醇甲基醚甲基丙烯酸酯（PEGME）对木质素进行改性，然后将改性的木质素自组装成微球，应用于具有温度响应性的木质素基Pickering乳液。由于接枝聚合物的热响应性，改性木质素微球的粒径随温度变化，这也会影响乳液液滴的半径。改性木质素的较低临界溶液温度（LCST）为50 °C。当温度从25变化时 °C至70 °C时，木质素微球的平均粒径从159 nm至141 nm。进一步升高的温度导致木质素微球团聚并破坏Pickering乳液。制备的Pickering乳液具有良好的载药性能和稳定的释放性能。研究发现，14年后药物的累积释放率从43.77%变为80%以上小时，25 °C及以上50 °C。木质素基Pickering乳液具有良好的热循环稳定性和离子抗性，这可能为药物释放提供了潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Wood Chemistry and Technology 工程技术-材料科学：纸与木材

CiteScore

3.70

自引率

20.00%

发文量

审稿时长

3 months

期刊介绍： The Journal of Wood Chemistry and Technology (JWCT) is focused on the rapid publication of research advances in the chemistry of bio-based materials and products, including all aspects of wood-based polymers, chemicals, materials, and technology. JWCT provides an international forum for researchers and manufacturers working in wood-based biopolymers and chemicals, synthesis and characterization, as well as the chemistry of biomass conversion and utilization. JWCT primarily publishes original research papers and communications, and occasionally invited review articles and special issues. Special issues must summarize and analyze state-of-the-art developments within the field of biomass chemistry, or be in tribute to the career of a distinguished researcher. If you wish to suggest a special issue for the Journal, please email the Editor-in-Chief a detailed proposal that includes the topic, a list of potential contributors, and a time-line.