Treatment of Capsular Contracture After Radiotherapy in Breast Reconstruction.

Abstract

in the treatment area and the complications that may occur. It has been reported that silicone breast prostheses have no negative effect on photon and electron dose distribution. In addition, it was determined that the silicone elastomer used in breast prostheses did not reduce the radiation transmission (9). There is not enough information in the literature regarding the prevention / treatment of complications in prostheses after RT. In studies performed, it was shown that complications of complications such as capsular contracture (1.3-15%) and worse cosmetic results and reconstruction after radiotherapy treatment have increased in patients with breast reconstruction with silicone implant (2, 3, 6-8). However, most of the current studies are retrospective cohort studies and there is no prospective study. The effects of radiation on the formation of capsules are tried to be explained. Recent studies have shown that the transforming growth factor- β (TGF- β 1) is an important factor in the formation of fibrosis and radiation-induced capsule formation. Positive results have been reported in studies to prevent these effects by inhibition of TGF- β signal transduction (3). Evans et al. (4) performed breast reconstruction with implants and compared the contracture stage, pain and extrusion in patients with RT without RT. They reported that radiotherapy increased the capsular contracture stage (Baker III, IV) and had significant negative consequences for the clinical appearance and patient satisfaction. Azzi et al. (5) reported that radiotherapy accelerated the process of capsular contracture around the silicone implant in a study of 105 patients.